Table 3

Transcription factors can be targeted by drugs or nutritional interventions (5, 9)

Molecular targetIntervention
AP-1Curcumin, gingerol, EGCG
NF-κBCurcumin, sulforaphane, NSAIDs
ERTamoxifen, raloxifene
HIF-1Gingerol
STAT3Curcubatacin-Q
p53Resveratrol, CP31398
Nrf2Sulforaphane, oltipraz, triterpenoids

Abbreviations: EGCG, epigallocatechin-3-gallate; NSAIDs, nonsteroidal anti-inflammatory drugs; ER, estrogen receptor; HIF-1, hypoxia-inducible factor 1.