Table 3

EGFR mutation and protein overexpression in histologically normal epithelium by location

EGFR abnormality in NBELocation in relation to the tumorStructure
InsideAdjacentDistantBronchioleSmall bronchus
Mutation
 Mutant tumor11/31 (36%)*10/35 (29%)1/17 (6%)*10/43 (23%)12/42 (29%)
 Wild-type tumor2/15 (13%)3/28 (11%)1/15 (7%)4/34 (12%)2/23 (9%)
 All tumors13/46 (28%)13/63 (21%)2/32 (6%)14/77 (19%)14/65 (22%)
EGFR overexpression
 Mutant tumor24/29 (83%)20/33 (61%)8/16 (50%)18/38 (47%)§34/40 (85%)§
 Wild-type tumor10/15 (67%)17/28 (61%)8/13 (62%)14/33 (42%)§21/23 (91%)§
 All tumors34/44 (77%)37/61 (61%)16/29 (55%)32/71 (45%)§55/63 (87%)§
pEGFR overexpression
 Mutant tumor13/29 (45%)5/33 (15%)6/16 (38%)10/38 (26%)14/40 (35%)
 Wild-type tumor5/15 (33%)5/28 (18%)2/13 (15%)2/33 (6%)§10/23 (44%)§
 All tumors18/44 (41%)10/61 (16%)8/29 (28%)12/71 (17%)24/63 (38%)
  • *Comparison of NBE from inside tumor vs. NBE distant (P = 0.02).

  • Positive immunohistochemical overexpression score >200 (range 0-400).

  • Comparison of NBE from inside tumor vs. NBE adjacent + distant (P = 0.02)

  • §Comparison of NBE from bronchiole vs. small bronchus (P < 0.001).

  • Comparison of NBE from inside tumor vs. NBE adjacent + distant (P = 0.038).

  • Comparison of NBE from bronchiole vs. small bronchus (P = 0.006).