Table 3

Comparison of men with and without prostatectomy verification of biopsy result

No prostatectomyProstatectomyOR (95% CI)*P-value*
n= 1,517n= 500
Treatment arm
 Finasteride617 (41%)206 (41%)0.97 (0.78-1.21)0.80
 Placebo900 (59%)294 (59%)1.0 (reference)
Age at randomization64.6 ± 5.661.1 ± 4.20.86 (0.84-0.88)<0.0001
1.0 (reference)
Race
 White1,403 (92%)466 (93%)1.41 (0.94-2.16)0.11
 Other114 (8%)34 (7%)1.0 (reference)
Family history of prostate cancer
 Yes317 (21%)117 (23%)1.02 (0.78-1.31)0.90
 No1,200 (79%)383 (77%)1.0 (reference)
PSA at randomization1.6 ± 0.81.7 ± 0.71.25 (1.07-1.82)0.006
1.0 (reference)
Prior negative biopsy
 Yes206 (14%)67 (13%)1.05 (0.76-1.44)0.78
 No1,311 (86%)433 (87%)1.0 (reference)
Biopsy prompt for PSA
 Yes350 (23%)154 (31%)1.4 (1.07-1.82)0.01
 No1,167 (77%)346 (69%)1.0 (reference)
Biopsy prompt for DRE
 Yes281 (19%)123 (25%)1.69 (1.30-2.18)<0.0001
 No1,236 (81%)377 (75%)1.0 (reference)
High grade on biopsy
 Yes391 (26%)149 (30%)1.26 (0.98-1.61)0.07
 No1,126 (74%)351 (70%)1.0 (reference)
  • *From a multivariable logistic regression model with prostatectomy (yes/no) as the outcome, adjusting for other factors in Table 3.