Table 2

Frequency of EGFR gene mutation and protein overexpression in histologically normal bronchial and bronchiolar epithelium obtained from EGFR-mutant and wild-type lung adenocarcinomas

EGFR abnormality in NBECasesSites
MutantWild-typeTotalMutantWild-typeTotal
Mutation by sequencing
 Number2426508557142
 Mutant12 (50%)*3 (12%)*15 (30%)22 (26%)8 (14%)30 (21%)
Protein overexpression by immunohistochemistry
 Number2326497856134
 EGFR19 (83%)15 (58%)34 (69%)52 (67%)35 (63%)87 (65%)
 pEGFR10 (44%)6 (23%)16 (33%)24 (31%)12 (21%)36 (27%)
  • *P = 0.003.

  • Positive immunohistochemical overexpression score >200 (range, 0-400).