Table 4

Summary of EGFR abnormalities by sites in nine primary lung adenocarcinomas and corresponding lymph node metastases

EGFR abnormality/number of sitesPrimary tumorMetastases
Mutation
 Number of sites examined5630
 Mutation positive54 (96%)*25 (83%)*
Copy no.
 Number of sites examined4229
 Low copy no.9 (21%)4 (14%)
 High copy no.33 (79%)25 (86%)
  High polysomy22 (52%)18 (62%)
  Gene amplification11 (26%)7 (24%)
Protein overexpression
 Number of sites examined6531
 EGFR42 (65%)30 (97%)
 pEGFR9 (14%)§21 (68%)§
  • *The same case harbored two primary tumor and five metastasis sites with EGFR-wild-type sequence.

  • Positive immunohistochemical expression score >200 (range 0-400).

  • Primary tumor vs. metastasis (P = 0.02).

  • §Primary tumor vs. metastasis (P = 0.00001).