Table 2

Treatment of MSK-Leuk1 cells with TS affected pathways related to cell proliferation, inflammation, apoptosis, coagulation, and tumor suppression

0.5 h3 h6 h12 h24 h
P(genes/path)
KEGG pathways
 Cytokine-cytokine receptor interaction↑0.0025(84/257)↑<1e−4(86/257)↑9e−04(83/257)↑0.0008(79/257)↑0.0025(83/257)
 Prostaglandin and leukotriene metabolism↑0.0447(15/39)↓0.007(15/39)↑0.044(15/39)↑0.008(15/39)↑0.0025(15/39)
 Neuroactive ligand-receptor interaction↑0.0025(43/295)↓0.032(46/295)↓0.02(51/295)↑0.0025(39/295)↑<1e−4(46/295)
 γ-Hexachlorocyclohexane degradation↑0.0092(13/45)↑0.003(13/45)↑0.008(13/45)↑0.0025(11/45)↑0.0041(14/45)
 Hedgehog signaling pathway↑0.0117(21/53)↑0.003(21/53)↓0.009(23/53)↑0.0025(20/53)↓0.0025(22/53)
 Complement and coagulation cascades↑0.0025(20/69)↑0.003(21/69)↑0.008(21/69)↑0.0025(18/69)↑0.0025(19/69)
 Porphyrin and chlorophyll metabolism↓0.003(16/32)↑0.011(16/32)↑0.0132(16/32)↑0.0203(16/32)
 Amino sugar metabolism↑0.0025(24/27)↓0.007(24/27)↑0.0349(24/27)↑0.0218(24/27)
 Jak-STAT signaling pathway↑0.0025(81/159)↑0.012(81/159)↑0.0025(78/159)↑0.0025(81/159)
Biocarta pathways
 Msp/Ron receptor signaling pathway↓0.0001(4/6)↓0.0025(5/6)↓0.0134(5/6)↓0.01(5/6)↓0.0025(5/6)
 Cytokine network↑0.0025(5/22)↑0.0025(5/22)↑0.0025(5/22)↑0.003(5/22)↑0.0025(5/22)
 Regulation of hematopoiesis by cytokines↑0.0025(6/15)↑0.0025(6/15)↑0.0418(6/15)↑0.046(6/15)↑0.0025(6/15)
 Cytokines and inflammatory response↑0.0025(11/29)↑<1e−4(11/29)↑0.0008(11/29)↑0.003(11/29↑<1e−4(11/29)
 Fibrinolysis pathway↑0.0025(6/12)↑0.0049(6/12)↑0.0025(6/12)↑0.003(5/12)↑0.0044(6/12)
 Mechanism of acetaminophen activity and toxicity↑0.0025(3/6)↑0.0025(3/6)↑0.0025(3/6)↑<1e−4(3/6)↑0.0025(3/6)
 Signal transduction through IL1R↑0.0152(28/33)↑0.0025(28/33↑0.0095(28/33)↑0.003(28/33)↑0.0044(28/33)
 Erythrocyte differentiation pathway↑0.0025(7/15)↑0.0025(7/15)↑0.0025(7/15)↑0.013(7/15)↑0.0044(7/15)
 Mechanism of gene regulation by peroxisome proliferators via PPARa↑0.0025(43/57)↑0.0197(42/57)↑0.013(42/57)↑0.0096(42/57)
 Cells and molecules involved in local acute inflammatory response↑0.0025(7/17)↑0.0364(8/17)↓0.0169(8/17)↑0.0025(7/17)
 IL-10 anti-inflammatory signaling pathway↑0.0025(11/13)↓0.0076(11/13)↑0.0025(11/13)↓0.0025(11/13)
 Stress induction of HSP regulation↑0.0025(12/15)↑0.0025(12/15)↑0.006(11/15)↓0.0044(11/15)
 Extrinsic prothrombin activation pathway↑0.0393(5/13)↑0.0291(4/13)↑0.013(4/13)↑0.0189(4/13)
 p53 signaling pathway↓0.0076(13/15)↓0.0446(14/15)↓0.013(13/15↓0.0025(13/15)

NOTE: P values are presented. Complete lists per time point are provided at http://physiology.med.cornell.edu/go/smoke. Generated using PLAGE tool (31).