Table 3

Genes that are differentially expressed in both the airways of human smokers and MSK-Leuk1 cells exposed to TS for 0.5 to 24 h with associated P values

SymbolIDHuman airway0.5 h3 h6 h12 h24 hDescription
P
CYP1A1205749_at↑4.4e−04↑3.3e−06↑2.1e−08↑1.1e−07↑1.5e−06↑1.0e−05Cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1202436_s_at↑1.7e−07↑4.3e−06↑4.5e−05↑5.5e−08↑1.5e−06↑6.6e−04Cytochrome P450, family 1, subfamily B, polypeptide 1
CYP1B1202437_s_at↑8.5e−08↑4.2e−06↑4.0e−06↑1.7e−06↑5.5e−06↑2.1e−08Cytochrome P450, family 1, subfamily B, polypeptide 1
GCLM203925_at↑1.8e−05↑1.5e−03↑1.3e−03↑3.4e−04↑1.8e−04↑3.5e−03Glutamate-cysteine ligase, modifier subunit
TXNRD1201266_at↑6.0e−07↑1.2e−02↑2.7e−04↑4.9e−05↑8.8e−05↑1.6e−03Thioredoxin reductase 1
ALDH1A3203180_at↑1.5e−04↑1.9e−04↑9.8e−09↑2.8e−06↑1.3e−03↑2.8e−04Aldehyde dehydrogenase 1 family, member A3
NQO1201468_s_at↑2.8e−13↑4.7e−05↑2.3e−05↑1.3e−06↑6.6e−04↑1.8e−04NAD(P)H dehydrogenase, quinone 1
NQO1201467_s_at↑4.7e−123.2e−02>0.05↑9.0e−05↑4.0e−03↑4.8e−03NAD(P)H dehydrogenase, quinone 1
PIR207469_s_at↑1.3e−12>0.05>0.05↑2.8e−02↑3.1e−02↑3.2e−02Pirin
AKR1C1204151_x_at↑1.4e−10↓2.8e−02>0.05↑3.8e−03↑1.5e−02↑6.0e−04Aldo-keto reductase family 1, member C1
NQO1210519_s_at↑3.1e−14↓4.7e−02↑1.3e−02↑2.0e−05↑2.1e−03↑3.7e−04NAD(P)H dehydrogenase, quinone 1
AKR1C1216594_x_at↑1.2e−09>0.05>0.05↑2.4e−04↑8.1e−03↑9.3e−03Aldo-keto reductase family 1, member C1
AKR1C2211653_x_at↑4.0e−12>0.05>0.05↑9.6e−03↑2.3e−02↑1.6e−04Aldo-keto reductase family 1, member C2
AKR1C2209699_x_at↑2.5e−14↑3.8e−02>0.05↑2.5e−03>0.05↑4.4e−04Aldo-keto reductase family 1, member C2
MMP10205680_at↓5.6e−04>0.05>0.05↓2.2e−02>0.05>0.05Matrix metalloproteinase 10 (stromelysin 2)