Table 4

Comparison of modulation of promoter methylation status between oral and bronchial epithelia after 3-mo intervention

Oral baseline/3 monBronchial methylation index (baseline/3 mo)
Mean ± SD, median (range)P*
p16
 M/M7−0.16 ± 0.19, −0.17 (−0.5-0)0.003
 M/U16−0.15 ± 0.40, −0.17 (−0.67-0.67)
 U/M280.16 ± 0.34, 0.17 (−0.50-1.00)
 U/U71−0.05 ± 0.28, 0 (−0.83-0.67)
FHIT
 M/M3−0.11 ± 0.25, −0.17 (−0.33-0.17)<0.0001
 M/U16−0.46 ± 0.30, −0.50 (−0.83-0)
 U/M100.42 ± 0.33, 0.42 (−0.17-1.00)
 U/U950.01 ± 0.22, 0 (−0.50-1.00)
p16/FHIT
 M/M16−0.06 ± 0.37, −0.17 (−0.83-0.67)0.007
 M/U23−0.22 ± 0.38, −0.33 (−0.83-0.50)
 U/M270.16 ± 0.37, 0.17 (−0.50-1.00)
 U/U59−0.05 ± 0.31, 0 (−0.83-0.50)
  • *Kruskal-Wallis test comparing bronchial brush methylation index modulation among oral brush methylation modulation groups.