Table 3.

Associations of rs6028466, rs621559 and rs654128 with bladder cancer risk

GenotypeOverallNever smokerEver smoker
CaseControlOR (95% CI)PCaseControlOR (95% CI)PCaseControlOR (95% CI)P
rs6028466
 GG867848Ref.230357Ref.636491Ref.
 GA1021070.93 (0.69–1.25)0.6126490.82 (0.49–1.36)0.4476580.93 (0.69–1.25)0.62
 AA02N/A a01N/A01N/A
AdditiveN/AN/AN/A
 Dominant (GA + AA vs. GG)0.91 (0.68–1.22)0.530.80 (0.49–1.33)0.390.98 (0.67–1.42)0.91
 Recessive (AA vs. GG + GA)N/AN/AN/A
rs621559
 GG837822Ref.218352Ref.618470Ref.
 GA1271230.98 (0.74–1.29)0.8735481.17 (0.73–1.87)0.5192750.89 (0.63–1.25)0.49
 AA4120.39 (0.12–1.23)0.11370.65 (0.17–2.57)0.5415N/A
 Additive0.89 (0.70–1.14)0.371.03 (0.70–1.53)0.86N/A
 Dominant (GA + AA vs. GG)0.93 (0.71–1.21)0.591.10 (0.70–1.73)0.670.84 (0.60–1.18)0.32
 Recessive (AA vs. GG + GA)0.39 (0.12–1.23)0.110.64 (0.16–2.51)0.52N/A
rs654128
 GG695701Ref.178298Ref.517403Ref.
 GT2432351.06 (0.86–1.32)0.57681001.14 (0.80–1.64)0.471741351.02 (0.78–1.34)0.86
 TT31211.62 (0.91–2.89)0.101091.80 (0.71–4.52)0.2121121.55 (0.74–3.20)0.25
 Additive1.13 (0.95–1.36)0.171.21 (0.90–1.63)0.211.09 (0.87–1.37)0.43
 Dominant (GT + TT vs. GG)1.11 (0.90–1.36)0.331.20 (0.85–1.69)0.311.07 (0.82–1.38)0.63
 Recessive (TT vs. GG + GT)1.60 (0.90–2.84)0.111.74 (0.69–4.35)0.241.54 (0.74–3.20)0.25

Abbreviations: N/A, not applicable; Ref., reference value.

  • aThe number of homozygous variant genotype was 5 or less in both cases and controls; only dominant model was applied.