Table 2.

Associations between breast cancer outcomes and prediagnosis physical activity (N = 4,643)

0 MET-h/wk>0–3.0 MET-h/wk3.1–8.9 MET-h/wk9+ MET-h/wkPtrend
Moderate- to vigorous-intensity physical activity from walking and recreational activitiesa
Total no. of deaths (n = 350)1194070121
 Age-adjusted HR (95% CI)1.000.79 (0.56–1.14)0.60 (0.45–0.81)0.55 (0.43–0.71)0.0001
 Multivariable-adjusted HR (95% CI)1.000.81 (0.56–1.16)0.67 (0.50–0.91)0.61 (0.47–0.81)0.0004
No. of breast cancer deaths (n = 194)61214369
 Age-adjusted HR (95% CI)1.000.81 (0.49–1.32)0.72 (0.49–1.07)0.61 (0.44–0.87)0.0054
 Multivariable-adjusted HR (95% CI)1.000.83 (0.51–1.37)0.82 (0.55–1.22)0.71 (0.49–1.03)0.073
Moderate-intensity physical activity from walking and recreational activities, adjusted for vigorous-intensity physical activityb
Total no. of deaths (n = 350)129479183
 Age-adjusted HR (95% CI)1.000.79 (0.56–1.10)0.68 (0.52–0.89)0.52 (0.40–0.69)0.0001
 Multivariable-adjusted HR (95% CI)1.000.81 (0.58–1.13)0.75 (0.57–0.99)0.58 (0.44–0.78)0.0003
No. of breast cancer deaths (n = 194)68285444
 Age-adjusted HR (95% CI)1.000.87 (0.56–1.36)0.77 (0.54–1.10)0.54 (0.37–0.79)0.0014
 Multivariable-adjusted HR (95% CI)1.000.91 (0.58–1.41)0.87 (0.60–1.25)0.60 (0.40–0.90)0.014

NOTE: Physical activity assessed at baseline visit (i.e., prediagnosis). Adjusted for age, ethnicity, WHI study arm, previous hormone therapy use, BMI, diabetes, alcohol, smoke, total calories, percentage calories from fat, and servings of fruit and vegetables.

a0 MET-h/wk, n = 1,119; >0–3.0 MET-h/wk, n = 473; 3.1–8.9 MET-h/wk, n = 1,065; 9+ MET-h/wk, n = 1,986.

b0 MET-h/wk, n = 1,275; >0–3.0 MET-h/wk, n = 600; 3.1–8.9 MET-h/wk, n = 1,283; 9+ MET-h/wk, n = 1,485.