Table 3.

Associations between breast cancer outcomes and postdiagnosis physical activity (N = 2,910)

0 MET-h/wk >0–3.0 MET-h/wk 3.1–8.9 MET-h/wk 9+ MET-h/wk Ptrend
Moderate- to vigorous-intensity physical activity from walking and recreational activitiesa
Total no. of deaths (n = 186)83103855
 Age-adjusted HR (95% CI)1.00 0.42 (0.22–0.81) 0.68 (0.46–1.00) 0.48 (0.34–0.67)0.0001
 Multivariable-adjusted HR (95% CI)1.00 0.42 (0.21–0.82)0.72 (0.48–1.07) 0.54 (0.38–0.79)0.0014
No. of breast cancer deaths (n = 86)3632027
 Age-adjusted HR (95% CI)1.00 0.28 (0.09–0.91)0.79 (0.46–1.36) 0.51 (0.31–0.84)0.0077
 Multivariable-adjusted HR (95% CI)1.00 0.30 (0.09–0.99)0.77 (0.43–1.38) 0.61 (0.35–0.99)0.049
Moderate-intensity physical activity from walking and recreational activities, adjusted for vigorous-intensity physical activityb
Total no. of deaths (n = 186)87144243
 Age-adjusted HR (95% CI)1.00 0.48 (0.27–0.84) 0.65 (0.45–0.94) 0.52 (0.36–0.76)0.0006
 Multivariable-adjusted HR (95% CI)1.00 0.50 (0.28–0.89)0.70 (0.48–1.03) 0.62 (0.41–0.93)0.020
No. of breast cancer deaths (n = 86)3952220
 Age-adjusted HR (95% CI)1.00 0.37 (0.15–0.94)0.71 (0.42–1.20) 0.51 (0.30–0.87)0.014
 Multivariable-adjusted HR (95% CI)1.000.43 (0.16–1.12)0.74 (0.42–1.30)0.66 (0.36–1.21)0.18

NOTE: Physical activity assessed at visit closest to diagnosis (i.e., either year 3 or year 6). Adjusted for age, stage, ER, PR, grade, HER2, ethnicity, WHI study arm, previous hormone therapy use, time from diagnosis to physical activity assessment, BMI, diabetes, alcohol, smoke, total calories, and percentage calories from fat, and servings of fruit and vegetables.

a0 MET-h/wk, n = 907; >0–3.0 MET-h/wk, n = 253; 3.1–8.9 MET-h/wk, n = 570; 9+ MET-h/wk, n = 1,180.

b0 MET-h/wk, n = 1,008; >0–3.0 MET-h/wk, n = 332; 3.1–8.9 MET-h/wk, n = 696; 9+ MET-h/wk, n = 874.