Table 3.

Results of ROC analyses of the methylation levels in 4 genes in the training set.

Tumor sizeTraining set
GenesAUCCutoff (%)SensitivitySpecificityORs
Estimate (95% CI)Estimate (95% CI)Estimate (95% CI)Estimate (95% CI)
TotalmiR34b/c0.796 (0.686–0.906)13.00.861 (0.705–0.953)0.647 (0.465–0.803)11.4 (3.5–36.9)
17.80.833 (0.609–0.899)0.765 (0.588–0.893)16.3 (5.0–53.0)
21.00.611 (0.435–0.769)0.882 (0.726–0.967)11.8 (3.4–40.7)
SFRP10.736 (0.616–0.857)45.00.750 (0.578–0.879)0.706 (0.525–0.849)7.2 (2.5–20.7)
SFRP20.688 (0.562–0.814)33.00.583 (0.408–0.745)0.765 (0.588–0.893)4.5 (1.6–12.8)
DKK20.702 (0.572–0.831)11.00.806 (0.64–0.918)0.647 (0.465–0.803)7.6 (2.6–22.5)
≥25mmmiR34b/c0.816 (0.665–0.967)15.00.862 (0.683–0.961)0.667 (0.223–0.957)12.5 (1.7–92.3)
<25mmSFRP10.810 (0.594–1.000)51.00.821 (0.631–0.939)0.833 (0.359–0.996)23.0 (2.2–242.1)