Table 4.

Results of ROC analyses of the methylation levels in 4 genes in the test set.

Test set
AUCCutoff (%)SensitivitySpecificityORs
Tumor sizeGenesEstimate (95% CI)Estimate (95% CI)Estimate (95% CI)Estimate (95% CI)
TotalmiR34b/c0.915 (0.833–0.997)13.00.870 (0.664–0.972)0.875 (0.676–0.973)46.7 (8.4–258.9)
17.80.565 (0.345–0.768)0.958 (0.789–0.999)29.9 (3.4–260.6)
21.00.348 (0.164–0.573)1.000 (0.858–1.000)N/A
SFRP10.752 (0.615–0.889)45.00.348 (0.164–0.573)0.875 (0.676–0.973)3.7 (0.8–16.4)
≥25mmmiR34b/c0.778 (0.000–1.000)15.00.667 (0.410–0.867)0.667 (0.094–0.991)4.0 (0.3–53.5)
<25mmSFRP10.695 (0.450–0.941)51.00.200 (0.005–0.716)1.000 (0.839–1.000)N/A