Table 1.

OR and 95% CI of colorectal cancer according to plasma vitamin D metabolites in the Physicians' Health Study

CategoriesaColorectal cancerColon cancerRectal cancer
No. of cases/ controlsMedianSimple matched OR (95% CI)bMultivariate ORcNo. of cases/ controlsMultivariate OR (95% CI)cNo. of cases/ controlsMultivariate OR (95% CI)c
25(OH)D, ng/mL
 Quartile157/9615.71.001.0036/701.0020/241.00
 Quartile241/9722.30.72 (0.43–1.20)0.71 (0.42–1.21)37/720.95 (0.52–1.74)15/260.53 (0.18–1.60)
 Quartile374/9926.71.26 (0.78–2.02)1.24 (0.76–2.04)52/741.34 (0.75–2.39)9/280.42 (0.13–1.40)
 Quartile457/9737.91.02 (0.62–1.69)1.08 (0.62–1.87)47/711.38 (0.73–2.64)13/240.45 (0.14–1.46)
P for trend0.990.670.350.05
1,25(OH)2D, pg/mL
 Quartile166/9325.51.001.0049/681.0020/241.00
 Quartile260/9631.20.87 (0.54–1.41)0.91 (0.55–1.50)40/710.83 (0.46–1.49)13/240.57 (0.20–1.60)
 Quartile353/9634.70.79 (0.49–1.27)0.84 (0.51–1.38)47/710.96 (0.54–1.68)10/260.43 (0.13–1.39)
 Quartile445/9441.10.66 (0.39–1.09)0.70 (0.41–1.18)33/710.64 (0.34–1.19)12/240.75 (0.27–2.09)
P for trend0.140.240.220.72

aAmong control participants, quartile cutoff points were determined by season (summer/autumn or winter/spring) and batches (2 batches).

bMatched on age (±1 year for younger participants, ±5 years for older participants) and smoking status (never, past, current).

cMatched on age (±1 year for younger participants, ±5 years for older participants) and smoking status (never, past, current). Further adjusted for seasons (summer/autumn or winter/spring), fasting status (≤8, >8 hours), race (Caucasian or non-Caucasian), vigorous exercise (<1, 1–4, ≥5 times/wk), dairy calcium intake (≤146, 146 to <340, 340 to <580, ≥580 mg/d), and BMI (<23, 23 to <25, 25 to <27, ≥27 kg/m2).