Table 3.

Means, differences, and SDs of hormonal network biomarkers (μmol/L) for the soy arm of the intervention (N = 55)a

BiomarkerMean (SD)Pc
Week 14Week 24Differenceb
IGF-I129.5 (42.1)151.0 (71.1)21.6 (59.1)0.001
IGFBP-32,062.3 (462.8)2,217.0 (550.4)154.7 (343.8)0.001
Estradiol14.2 (4.7)14.6 (6.5)0.37 (5.1)0.36
SHBG53.1 (27.2)47.6 (26.0)−5.43 (9.4)<0.001
C-peptide4.5 (2.3)4.4 (2.3)−0.12 (1.2)0.50
Insulin11.0 (9.2)10.4 (6.7)−0.62 (6.3)0.79
  • aFour women were excluded because of a late follow-up, and 11 women were lost to follow-up.

  • bDifference is calculated as follows: week 24 − week 14.

  • cP values were calculated using exact Wilcoxon signed-rank tests (nonparametric mean pairwise tests).