Table 1.

P53 mutations and drug resistance in neuroblastoma cell lines

Status of p53Cell linep53 MutationIC50 (μmol/L)
DOXCDDP
MutatedCHLA90E286K0.60 ± 0.130 ± 4
SK-N-BE(2)C135F0.88 ± 0.122 ± 2
Wild-typeSMS-KCNR0.02 ± 0.04 ± 1
LAN-50.02 ± 0.010 ± 1

NOTE: Drug sensitivity assays were carried out by MTT to determine IC50 values. The values are presented as mean ± SD from 3 separate determinations with 8 replicates each (n = 24).