Table 5.

Distribution of iron-related genotypes and risk of colorectal adenoma (n = 770 cases and 777 controls) in the PLCO Cancer Screening Trial

GenotypeCases, nControls, nORa (95% CI)
TF
IVS8− 318T>G
 TT3363411.0 (Ref)
 GT3133270.97 (0.78–1.21)
 GG98861.14 (0.82–1.58)
Ptrend0.84
IVS11+ 437C>T
 CC5185301.0 (Ref)
 CT1951931.04 (0.82–1.32)
 TT24241.02 (0.57–1.83)
Ptrend0.96
IVS15+ 556T>C
 TT4434021.0 (Ref)
 TC2533120.73 (0.59–0.91)
 CC51441.05 (0.68–1.61)
Ptrend0.03
Ex15+ 78C>T
 CC4895181.0 (Ref)
 CT2091911.13 (0.90–1.43)
 TT23171.60 (0.84–3.05)
Ptrend0.42
TFRC
IVS1+ 1014A>G
 CC6226351.0 (Ref)
 CA94921.03 (0.76–1.41)
 AA651.20 (0.36–3.98)
Ptrend0.95
Ex4− 11G>A
 GG2072211.0 (Ref)
 GA3753631.11 (0.88–1.42)
 AA1571730.96 (0.72–1.29)
Ptrend0.24
IVS17+ 445C>T
 CC2953061.0 (Ref)
 CT3473341.09 (0.88–1.36)
 TT991160.92 (0.67–1.26)
Ptrend0.36
Ex19− 630A>G
 AA3443471.0 (Ref)
 AG3203290.98 (0.79–1.22)
 GG72730.98 (0.68–1.40)
Ptrend0.82
HMOX1
IVS1+ 429G>A
 GG3083091.0 (Ref)
 GA3413410.97 (0.78–1.21)
 AA92950.97 (0.70–1.35)
Ptrend0.99
Ex1− 5G>C
 GG6636601.0 (Ref)
 GC77760.99 (0.71–1.39)
 CC150.23 (0.03–1.98)
Ptrend0.52
IVS3+ 244A>G
 AA2132101.0 (Ref)
 AG3683750.97 (0.76–1.23)
 GG1611670.97 (0.72–1.30)
Ptrend0.95
SLC40A1
IVS2+ 1646G>A
 GG2742791.0 (Ref)
 GA3493530.97 (0.77–1.22)
 AA1161220.95 (0.70–1.29)
Ptrend0.66
IVS5− 2142A>G
 AA4063991.0 (Ref)
 AG2652950.89 (0.71–1.10)
 GG56451.22 (0.80–1.86)
Ptrend0.41
Ex6− 98T>C
 TT2812881.0 (Ref)
 TC3343371.01 (0.81–1.27)
 CC1171210.96 (0.71–1.30)
Ptrend0.79
SLC11A2
IVS1− 130G>A
 GG2312281.0 (Ref)
 GA3513730.96 (0.76–1.21)
 AA1611421.12 (0.83–1.50)
Ptrend0.51
IVS15− 1125G>C
 GG5004971.0 (Ref)
 GC2172290.96 (0.76–1.20)
 CC27280.93 (0.54–1.61)
Ptrend0.91
Ex16− 456T>C
 TT2562521.0 (Ref)
 TC3413510.98 (0.78–1.23)
 CC1271161.07 (0.78–1.46)
Ptrend0.68
Ex16+ 1142G>A
 GG6716661.0 (Ref)
 GA69890.72 (0.52–1.01)
 AA110.80 (0.05–12.91)
Ptrend0.18
HAMP
1,039-bp 3′ of STP A>T
 AA3103291.0 (Ref)
 AT3363361.04 (0.84–1.30)
 TT91911.02 (0.73–1.42)
Ptrend0.33
IVS1− 251A>G
 AA2061901.0 (Ref)
 AG3873920.88 (0.69–1.13)
 GG1501700.78 (0.58–1.05)
Ptrend0.41
ACO1
IVS1− 7563C>T
 CC4023851.0 (Ref)
 CT2833190.87 (0.70–1.08)
 TT56471.17 (0.77–1.78)
Ptrend0.43
IVS1− 3873A>G
 AA3123111.0 (Ref)
 AG3463460.98 (0.78–1.21)
 GG861020.84 (0.61–1.17)
Ptrend0.45
IVS1+ 4665C>T
 CC4554411.0 (Ref)
 CT2482770.89 (0.72–1.11)
 TT46361.27 (0.80–2.00)
Ptrend0.46
IVS1+ 7051C>G
 CC1852001.0 (Ref)
 CG3643781.04 (0.81–1.33)
 GG1811641.18 (0.88–1.58)
Ptrend0.65
IVS1+ 9689C>T
 CC3643401.0 (Ref)
 CT3053310.89 (0.72–1.11)
 TT76830.87 (0.61–1.23)
Ptrend0.67
IVS2+ 665A>T
 AA2502851.0 (Ref)
 AT3633541.15 (0.92–1.45)
 TT1211081.27 (0.93–1.74)
Ptrend0.36
IVS4− 882C>T
 CC3793881.0 (Ref)
 CT3103021.09 (0.88–1.35)
 TT49650.78 (0.53–1.17)
Ptrend0.22
IVS4+ 793G>A
 GG5365311.0 (Ref)
 GA1791950.90 (0.71–1.14)
 AA14200.74 (0.37–1.50)
Ptrend0.39
IVS4+ 3642C>A
 CC5455461.0 (Ref)
 CA1881990.97 (0.77–1.22)
 AA12120.97 (0.43–2.18)
Ptrend0.88
IVS7− 505T>G
 TT3123251.0 (Ref)
 TG3443501.00 (0.81–1.25)
 GG87781.12 (0.79–1.58)
Ptrend0.88
IVS10− 160T>G
 TT2993011.0 (Ref)
 TG3343490.95 (0.76–1.19)
 GG95851.10 (0.78–1.54)
Ptrend0.86
IVS15− 752G>A
 GG2222341.0 (Ref)
 GA3553740.99 (0.78–1.25)
 AA1661511.13 (0.84–1.51)
Ptrend0.46
IVS15+ 90A>G
 AA3213241.0 (Ref)
 AG3063250.94 (0.75–1.17)
 GG101901.10 (0.79–1.52)
Ptrend0.79
HP01
IVS6+ 47C>A
 CC5345561.0 (Ref)
 CA2081971.09 (0.87–1.37)
 AA01
  • aAdjusted for age (≤59, 60–64, 65–69, 70–74, ≥75 years).