Table 2.

Multivariate linear model–CA125 cut-point (98th percentile) for each factor, percent change, and median CA125 value

Premenopausal subjectsPostmenopausal subjects
Factor98th percentileEffect (P)Median CA12598th percentileEffect (P)Median CA125
Baseline5217.83613.9
Black47−11% (0.090)1629−22% (0.0008)11.1
Asian41−24% (0.0090)14.1NSa
Irregular periods47−11% (0.0100)16.1NAb
Current OC use40−26% (<0.0001)13.8NA
No. of intact ovaries
 0NS30−18% (<0.0001)11.6
 1372% (0.7000)14.1
Fertility treatmentNS30−17% (0.0100)11.7
Current smoking45−15% (0.0003)15.433−8% (0.0500)12.7
Menopause age
 45|age = 50NA350.4% per year13.6
 50|age = 5536given13.7
 55|age = 6036age = 50 (0.01)14
Age
 <35 (30)49Nonlinear (0.03)16.9NANonlinear (0.01)NA
 35–45 (40)5418.5NANA
 45–55 (50)5217.83613.9
 55–65 (60)NANA3613.7
 > 65 (70)NANA3714.2
GOG48−7% (0.002)16.631−13% (<0.0001)12.1
  • aNot statistically significant (P > 0.05).

  • bNot applicable given menopause subgroup.