Table 1.

Study population: univariate analysis of CA125 median and cut-point (98th percentile) by menopausal status and other defining subgroup factors (pre-SD = 0.54, post-SD = 0.47)

Premenopausal subjectsPostmenopausal subjects
Factor98th percentile CA125 (median)n (%)P98th percentile CA125 (median)n (%)P
OCs<0.00010.2
 Never50 (16.8)400 (20%)32 (12.3)482 (29%) 
 Former51 (17.1)1,291 (63%)33 (12.7)1,174 (71%) 
 Current39 (13.1)345 (17%)NA (NA)0 (0%) 
No. of intact ovaries0.040.0005
 0NA (NA)0 (0%)30 (11.4)282 (17%) 
 157 (19.0)50 (2%)35 (13.1)80 (5%) 
 249 (16.2)1,986 (98%)34 (12.8)1,294 (78%) 
Irregular menstrual periods0.0030.5
 Yes44 (14.6)181 (9%)32 (12.3)168 (10%) 
 No49 (16.5)1,855 (91%)33 (12.6)1,488 (90%) 
Black0.20.004
 Yes45 (14.9)68 (3%)27 (10.4)52 (3%) 
 No49 (16.4)1,968 (97%)33 (12.6)1,604 (97%) 
Asian0.0050.9
 Yes38 (12.7)35 (2%)33 (12.7)10 (1%) 
 No49 (16.4)2,001 (98%)33 (12.5)1,646 (99%) 
Ashkenazi Jewish0.050.2
 Yes47 (15.6)400 (20%)32 (12.2)333 (20%) 
 No49 (16.5)1,636 (80%)33 (12.6)1,323 (80%) 
Hysterectomy0.40.02
 Yes45 (14.9)25 (1%)32 (12.0)531 (32%) 
 No49 (16.3)2,011 (99%)34 (12.8)1,125 (68%) 
Fertility treatment0.90.02
 Yes49 (16.4)86 (4%)28 (10.8)51 (3%) 
 No49 (16.3)1,950 (96%)33 (12.6)1,605 (97%) 
Smoking history0.050.3
 Never50 (16.7)1,304 (64%)34 (12.7)950 (57%) 
 Former43 (14.4)170 (8%)30 (11.5)131 (8%) 
 Current48 (16.0)562 (28%)33 (12.4)575 (35%) 
Family Hx of ovarian cancer0.040.2
 Yes48 (15.9)1,047 (51%)33 (12.3)730 (44%) 
 No50 (16.7)989 (49%)34 (12.7)926 (56%) 
BRCA1/2 mutation0.040.3
 Yes46 (15.3)361 (63%)30 (12.1)156 (38%)
 No50 (16.8)210 (37%)31 (12.7)259 (62%)
Breast cancer0.20.06
 Yes50 (16.7)604 (30%)34 (12.8)954 (58%)
 No48 (16.2)1,432 (70%)32 (12.2)702 (42%)
Family Hx of breast cancer0.10.9
 Yes49 (16.5)1,653 (81%)33 (12.5)1403 (85%)
 No47 (15.7)383 (19%)33 (12.6)253 (15%)
HRT0.90.1
 Never49 (16.3)1,464 (72%)33 (12.6)733 (44%)
 Former49 (16.2)456 (22%)34 (12.7)652 (39%)
 Current49 (16.4)116 (6%)31 (11.8)271 (16%)
Population0.0010.0004
 CGN51 (16.9)1,127 (55%)34 (12.9)1,124 (68%)
 GOG47 (15.6)909 (45%)31 (11.8)532 (32%)