Table 3.

Characteristic of nested matched case control studies on postmenopausal hormone concentrations and breast cancer risk by receptor status

Risk estimate
StudyCohortNo. of cases/controlsER+/ER−PR+/PR−ER+PR+/ER +PR−/ER− PR-HormonesScaleER-positiveER-negativePR-positivePR-negativeER+PR+ER+/PR-ER−PR−
Zeleniuch-Jacquotte et al. (11)New York University Women's Health Study130/24853/23E2 Free E2 SHBGLoge continuous1.9 (0.9–4.0) 3.3 (0.6–20.3) 1.0 (0.7–1.4)2.0 (0.7–5.6) 9.2 (0.4–200.6) 0.9 (0.9–1.0)− − −− − −− − −− − −− − −
Missmer et al. (14)Nurses Health Study322/643153/34/39E2 T SHBGQuartilesa− − −− − −− − −− − −3.3 (2.0–5.4)c 2.0 (1.2–3.4)c 0.5 (0.3–0.8)c1.0 (0.4–2.6) 1.9 (0.7–5.0) 1.8 (0.6–5.0)1.0 (0.4–2.4) 0.7 (0.3–1.6) 1.1 (0.5–2.8)
Cummings et al. (12)Osteoporotic Fractures Cohortb208/378196/-E2 TQuintilesa2.9 (1.6–5.1) 5.1 (2.5–10.3)− −− −− −− −− −− −
Kahan et al. (27)Hungarian Mammography Screening Program102/10264/23/10TQuartilesb5.8 (2.1–16.2)c
Sieri et al. (15)The ORDET Cohort165/672127/3096/5989/36/23E2 T Free T SHBGQuartilesa1.3 (0.8–2.0) 2.7 (1.6–4.3)c 1.6 (1.0–2.6)c 1.0 (0.6–1.6)0.9 (0.4–2.2) 1.6 (0.7–3.8) 1.9 (0.7–4.8) 0.8 (0.3–2.0)1.5 (0.8–2.5) 2.3 (1.3–4.1)c 1.7 (1.0–2.9)c 1.0 (0.6–1.7)0.9 (0.5–1.7) 2.5 (1.3-4.8)c 1.6 (0.8–3.0) 0.8 (0.4–1.6)1.5 (0.9–2.7) 2.3 (1.3–1.5)c 1.8 (1.0–3.1)c 1.0 (0.6–1.7)0.8 (0.4–1.8) 3.1 (1.3-7.2)c 1.2 (0.5–2.6) 1.0 (0.4–2.3)1.1 (0.4–2.9) 1.8 (0.7–4.8) 2.6 (0.8–8.4) 0.7 (0.3–1.8)
Baglietto et al. (13)Melbourne Collaborative Cohortb197/857132/4587/8983/48/41E2 FreeE2 T SHBGLog2 continuous1.5 (0.9–2.5)1.7 (0.7–4.0)1.5 (0.8–2.8)1.5 (0.8–2.9)1.7 (0.9–3.1)1.2 (0.5–2.8)2.0 (0.8–5.0)
1.7 (1.1–2.6)1.7 (0.9–3.3)2.0 (1.2–3.3)1.5 (0.9–2.4)2.3 (1.4–3.8)1.1 (0.6–2.1)2.1 (1.1–4.2)
1.1 (0.9–1.5)1.0 (0.7–1.5)1.1 (0.8–1.5)1.1 (0.8–1.5)1.1 (0.8–1.6)1.2 (0.8-1.7)1.1 (0.7–1.6)
0.4 (0.3–0.6)0.4 (0.2–0.8)0.3 (0.2–0.6)0.5 (0.3–0.8)0.3 (0.2–0.5)0.6 (0.4–1.1)0.4 (0.2–0.7)

E2: Estradiol.

Free E2: Free estradiol.

Free T: Free testosterone.

  • aEstimates in categories are highest vs. lowest.

  • bCase cohort study design.

  • cP < 0.05 on continuous trend.