Table 4.

Associations of exercise over the first 36 months after breast cancer diagnosis with total mortality and relapse/disease-specific mortality, stratified by menopausal status, QOL, and BMI

Total mortalityRelapse/disease-specific mortality
TotalEventsHR (95% CI)TotalEventsHR (95% CI)
Stratified by menopausal status a
Premenopause2,3591862,202208
 MET-hours per weekb
  No exercise835761.00773811.00
  <8.3764490.87 (0.58–1.10)714550.59 (0.39–0.89)
  ≥8.3760610.86 (0.58–1.26)715720.69 (0.47–1.00)
Ptrend0.3170.631
Postmenopause2,4672502,309242
 MET-hours per weekb
  No exercise8761091.00807931.00
  <8.3802730.82 (0.59–1.14)754730.63 (0.44–0.91)
  ≥8.3789680.55 (0.40–0.77)748760.52 (0.36–0.74)
Ptrend<0.0010.001
Pinteraction0.2330.300
Stratified by QOL c
QOL < median2,2782052,138222
 MET-hours per weekb
  No exercise9021011.00827991.00
  <8.3723560.63 (0.44–0.90)681590.45 (0.31–0.65)
  ≥8.3653480.50 (0.35–0.71)630640.47 (0.33–0.66)
Ptrend<0.0010.006
QOL ≥ median2,5482312,373228
 MET-hours per weekb
  No exercise809841.00753751.00
  <8.3843661.06 (0.73–1.55)787690.80 (0.53–1.21)
  ≥8.3896810.83 (0.58–1.21)833840.74 (0.50–1.10)
Ptrend0.1110.289
Pinteraction0.2940.218
Stratified by BMI d
BMI<253,1282672,914266
 MET-hours per weekb
  No exercise1,1021131.001,015981.00
  <8.3999760.76 (0.55–1.05)932810.70 (0.47–0.96)
  ≥8.31,027780.62 (0.45–0.85)967870.66 (0.47–0.94)
Ptrend0.0020.033
BMI ≥ 251,6981691,597184
 MET-hours per weekb
  No exercise609721.00565761.00
  <8.3567460.91 (0.60–1.38)536470.53 (0.35–0.81)
  ≥8.3522510.70 (0.46–1.05)496610.50 (0.38–0.74)
  Ptrend0.0270.095
Pinteraction0.6420.704
Stratified by Charlson comorbidity index
Charlson comorbidity index <13,8693393,601350
 MET-hours per weekb
  No exercise1,3601381.001,2531331.00
  <8.31,258980.89 (0.66,1.18)1,1721010.65 (0.47–0.89)
  ≥8.31,2511030.68 (0.50–0.90)1,1761160.66 (0.49–0.90)
Ptrend0.0030.162
Charlson comorbidity index ≥195797910100
 MET-hours per weekb
  No exercise351471.00327411.00
  <8.3308240.63 (0.36–1.10)296270.49 (0.26–0.78)
  ≥8.3298260.62 (0.37–1.05)287320.39 (0.23–0.66)
Ptrend0.0500.009
Pinteraction0.1980.651
  • aAdjusted for date of birth, BMI at baseline, waist-to-hip ratio at baseline, income, education, QOL, cruciferous vegetable intake, soy protein intake, tea consumption, chemotherapy, radiotherapy, tamoxifen use, TNM status, and ER/PR receptor status.

  • bExercise was treated as a time-dependent variable.

  • cFurther adjusted for TNM status instead of QOL.

  • dFurther adjusted for QOL instead of BMI.