Table 1.

Treatment plan showing groups of Sprague-Dawley rats treated with unmodified and nanoparticle forms of chemopreventive agents aspirin, folic acid, and calcium at various doses

SetGroup (n = 6)Treatment planDose, mg/kg
Set 1 (unmodified combination)G1Saline (control)0
G2AOM (control)0
G3ASP + FA + Ca400 + 32 + 650
G4ASP + FA + Ca133 + 11 + 216
G5ASP + FA + Ca40 + 3.2 + 65
G6ASP + FA + Ca13 + 1.1 + 22
G7ASP + FA + Ca4 + 0.32 + 6.5
Set 2 (unmodified and modified combination)G8Saline (control)0
G9AOM (control)0
G10ASP + FA + Ca133 + 11 + 216
G11ASP + FA + Ca80 + 6.4 + 130
G12ASP + FA + Ca40 + 3.2 + 65
G13ASP (NP) + FA (NP) + Ca133 + 11 + 216
G14ASP (NP) + FA (NP) + Ca80 + 6.4 + 130
G15ASP (NP) + FA (NP) + Ca40 + 3.2 + 65
Set 3 (modified combination)G16Saline (control)0
G17AOM (control)0
G18ASP (NP)40
G19FA (NP)3.2
G20Ca65
G21ASP (NP) + FA (NP) + Ca40 + 3.2 + 65

Abbreviations: ASP, aspirin; AOM, azoxymethane; FA, folic acid; Ca, calcium; NP, nanoparticles.