Table 2.

Associations of exercise after breast cancer diagnosis with total mortality and relapse/disease-specific mortality

HR (95% CI)
CharacteristicsTotalEventsFirst 6 mo postdiagnosisaFirst 18 mo postdiagnosisbFirst 36 mo postdiagnosisb
Total mortality4,826436
Exercise participation
 No1,7111851.001.001.00
 Yes3,1152510.80 (0.65–0.97)0.70 (0.56–0.87)0.70 (0.56–0.88)
Exercise participation per week, h
 No exercise1,7111851.001.001.00
 <2.51,6541260.78 (0.62–0.98)0.75 (0.59–0.96)0.84 (0.66–1.08)
 ≥2.51,4611250.82 (0.64–1.04)0.66 (0.51–0.84)0.64 (0.49–0.82)
Ptrend0.1680.0040.002
Exercise energy expenditure, MET-hours per week
 No exercise1,7111851.001.001.00
 <8.31,5661220.79 (0.63–0.99)0.77 (0.60–0.99)0.81 (0.63–1.05)
 ≥8.31,5491290.80 (0.63–1.02)0.65 (0.51–0.83)0.65 (0.51–0.84)
Ptrend0.1980.004<0.001
Relapse/disease-specific mortality4,511450
Exercise participation
 No1,5801741.001.001.00
 Yes2,9312760.91 (0.75–1.11)0.71 (0.57–0.90)0.60 (0.47–0.76)
Exercise participation per week, h
 No exercise1,5801741.001.001.00
 <2.51,5521330.84 (0.66–1.05)0.70 (0.54–0.90)0.63 (0.48–0.82)
 ≥2.51,3791431.01 (0.80–1.27)0.73 (0.57–0.94)0.57 (0.44–0.74)
Ptrend0.5220.3410.030
Exercise energy expenditure, MET-hours per week
 No exercise1,5801741.001.001.00
 <8.31,4681280.85 (0.67–1.07)0.70 (0.54–0.91)0.60 (0.46–0.78)
 ≥8.31,4631480.98 (0.78–1.24)0.72 (0.57–0.93)0.59 (0.45–0.76)
Ptrend0.4710.3240.006
  • aAdjusted for date of birth, BMI at baseline, waist-to-hip ratio at baseline, menopausal status, income, education, QOL, cruciferous vegetable intake, soy protein intake, tea consumption, chemotherapy, radiotherapy, tamoxifen use, TNM status, and ER/PR status.

  • bAdjusted for the same variables as above, but exercise was treated as a time-dependent variable.