Table 4.

Test performance of FIT and sigmoidoscopya for the detection of subjects with adenomas (n = 86) and those with advanced adenomas (n = 38)b in an average risk screening population (n = 329)

 AdenomasAdvanced adenomas
% (95% CI)% (95% CI)
Sigmoidoscopy
 Sensitivity68.6 (57.7–78.2)73.7 (56.9–86.6)
 Specificity100 (98.5–100.0)89.3 (85.2–92.7)
 PPV100 (93.2–100.0)47.5 (34.3–60.9)
 NPV90 (85.8–93.3)96.3 (93.3–98.2)
FIT, 50 ng cutoff
 Sensitivity8.1 (3.3–16.1)15.8 (6.0–31.3)
 Specificity96.7 (93.6–98.6)96.9 (94.2–98.6)
 PPV46.7 (21.3–73.4)40 (16.3–67.7)
 NPV74.8 (69.7–79.6)89.8 (85.9–92.9)
FIT, 27.5 ng cutoff
 Sensitivity15.1 (8.3–24.5)29 (15.4–45.9)
 Specificity94.7 91.0–97.1)94.9 (91.6–97.1)
 PPV50 (29.9–70.1)42.3 (23.4–63.1)
 NPV75.9 (70.7–80.6)91.1 (87.3–94.1)
  • aDefined as positive in case of colonoscopic findings located in the distal colon (i.e., rectum, sigmoid, and colon descendents) which would have led to a follow-up colonoscopy.

  • bDefined as lesions having size 10 mm or more, a villous component, and/or high-grade dysplasia.