Table 3.

Association between height, body shape at ages 5, 10, and 20 years and colorectal adenoma by subsite, stage, and age at diagnosis

Adenoma subsiteAdenoma stageAge at diagnosisc
Proximal (1,037 cases)Distal (1,119 cases)Rectal (403 cases)Nonadvanceda (1,037 cases)Advancedb (680 cases)< 50 y (1,098 cases) ≥ 50 y (1,229 cases)
OR(95% CI)OR(95% CI)OR(95% CI)OR(95% CI)OR(95% CI)OR(95% CI)OR(95% CI)
Height (in)
50–<621111111
62–<650.98(0.77–1.25)1.24(0.95–1.64)0.94(0.64–1.38)1.10(0.86–1.41)1.13(0.81–1.57)1.14(0.86–1.52)1.02(0.80–1.29)
65–<680.99(0.77–1.26)1.48(1.13–1.94)0.95(0.64–1.39)1.21(0.95–1.55)1.25(0.90–1.74)1.15(0.87–1.52)1.14(0.90–1.44)
≥681.06(0.81–1.39)1.71(1.28–2.29)0.98(0.64–1.52)1.24(0.95–1.63)1.44(1.00–2.07)1.38(1.01–1.88)1.20(0.93–1.56)
Ptrend0.47<0.00010.740.090.020.040.05
Pictogram at age 5 y
11111111
21.07(0.90–1.28)1.06(0.89–1.26)1.08(0.82–1.43)1.18(0.99–1.39)0.94(0.76–1.18)0.94(0.77–1.14)1.17(0.99–1.38)
31.18(0.99–1.42)1.11(0.93–1.34)1.14(0.85–1.54)1.29(1.08–1.53)0.99(0.79–1.26)1.12(0.92–1.37)1.18(0.99–1.40)
40.96(0.76–1.20)1.19(0.96–1.47)1.02(0.71–1.47)0.95(0.76–1.18)1.06(0.81–1.40)0.93(0.72–1.19)1.11(0.90–1.37)
≥51.12(0.85–1.46)1.40(1.09–1.79)1.12(0.73–1.72)1.23(0.95–1.58)1.29(0.94–1.78)1.20(0.89–1.61)1.40(1.11–1.77)
Ptrend0.430.010.570.350.140.270.01
Pictogram at age 10 y
11111111
21.08(0.90–1.31)1.05(0.87–1.27)0.90(0.67–1.21)1.08(0.90–1.30)0.95(0.74–1.21)0.94(0.76–1.17)1.06(0.89–1.27)
31.10(0.90–1.35)1.07(0.88–1.31)0.93(0.68–1.28)1.14(0.94–1.38)0.98(0.76–1.26)1.06(0.85–1.32)1.06(0.88–1.28)
41.05(0.84–1.30)1.15(0.93–1.42)0.97(0.69–1.37)0.95(0.77–1.18)1.13(0.86–1.49)0.95(0.75–1.22)1.13(0.92–1.38)
≥51.12(0.89–1.41)1.23(0.98–1.53)0.82(0.56–1.19)1.09(0.87–1.36)1.18(0.89–1.57)1.07(0.83–1.38)1.23(1.00–1.52)
Ptrend0.450.040.530.930.120.610.03
  • NOTE: Models for pictogram at age 5 or 10 years multivariate adjusted for age, family history of colorectal cancer, time period of endoscopy, number of reported endoscopies during the study period (1 endoscopy vs. ≥2 endoscopies), reason for most recent endoscopy, height (continuous), pack-years of smoking (0, 0–10, >10–20, >20–40, >40), current physical activity (quintiles), aspirin use (never, past, current 1 d/wk, 2–3 d/wk, 4–5 d/wk, ≥6 d/wk), current cumulative average alcohol intake (quintiles), current cumulative average dietary intake of red meat, processed meat, folate, and calcium (quintiles).Models for height adjusted for all variables mentioned above excluding height, but including current cumulative updated average BMI (continuous).aSize <1 cm and tubular.

  • bSize ≥1 cm or tubulovillous or villous or high-grade dysplasia.

  • cFor controls: age at most recent endoscopy.