Table 1.

Weight cycling and cancer risk: Epidemiologic studies

Cancer siteRisk assessmentAmplitudeaFrequencyDurationRef.
Breast (postmenopausal, prospective)OR = 1.0; 95% CI: 0.9–1.1≥20 lbs. lost; ≥10 lbs. regain≥1 cycle1 y(34)
Breast (postmenopausal, case control)OR = 2.11; 95% CI: 1.00–4.44≥Control median weight; <control medianNot indicatedAdult life(35)
Renal cell carcinoma (postmenopausal women, prospective)RR = 2.6; 95% CI: 1.6–4.2, Ptrend = 0.0005≥10 lbs.≥10 cyclesAdult life(36)
Renal cell carcinoma (case control)OR = 2.31; 95% CI: 1.04–5.12≥10 lbs.≥3 cyclesAdult life(38)
Endometrial (population-based case control)OR = 1.27; 95% CI: 1.00–1.61, Ptrend = 0.05≥20 lbs. lost; ≥ 10 lbs. regained1 cycle1 y(39)
Non-Hodgkin's lymphoma (postmenopausal women, prospective)HR = 1.97; 95% CI: 0.93–4.16, Ptrend = 0.09≥50 lbs.≥3 cycles20 y(37)
HR = 1.55; 95% CI: 1.00–2.40, Ptrend = 0.0520–49 lbs.≥3 cycles20 y
HR = 0.78; 95% CI: 0.46–1.33, Ptrend = 0.4010–19 lbs.≥3 cycles20 y
  • aClassification of weight cycling as defined in ref. 12.