Table 2.

Statistically significant nuclear features comprising DFs (P < 0.0001)

Feature descriptionStandardized coefficient
DF1Short segment of similar pixel intensities0.596
7–8 pixels with OD range of 0.3–0.6−0.402
2 pixels with OD range of 0.3–0.6 and 0.9–1.20.334
Frequency of pixels with OD range of 0.4–0.50.263
DF2A number of hyperchromatic pixels0.261
Long segment of similar pixel intensities−0.806
Frequency of 2 pixels with OD range of 0.3–0.6 and 0.6–0.90.25
DF3OD clumpness0.571
OD heterogeneity−0.597
Frequency of pixels with OD range of 1.0–1.10.381
DF4OD clumpness0.565
Pixel homogeneity0.556
Frequency of pixels with OD range of 1.0–1.10.473
Homogeneousa populationsHeterogenous pixel OD pattern−0.113
A long segment of similar pixel intensities1.465
A short segment of similar pixel intensities0.264
>11 pixels in a run with OD range of 0.3–0.6−0.873
A relatively high frequency of 2 pixels with OD range of 0.3–0.60.59
  • aHomogeneous refers to the DF that discriminates between nearly homogenous aggressive and nonaggressive population of nuclei.