Table 6.

Association between NSAID use and adenomatous polyp size

Adenomatous polypa
NSAID useControlsn≥1 cmn<1 cm
Never1,6541741.005711.00
Baby aspirin only701800.71 (0.52–0.97)2530.81 (0.67–0.98)
Regular aspirin only352390.64 (0.43–0.95)1370.75 (0.59–0.95)
Nonaspirin NSAIDs only343130.27 (0.15–0.48)1120.80 (0.63–1.03)
COX-2 inhibitor only7730.34 (0.10–1.13)180.70 (0.41–1.22)
Any combination of NSAIDs304200.37 (0.22–0.62)1050.66 (0.51–0.86)
Aspirin only, doses/wk
Never1,6541741.005711.00
<711980.60 (0.28–1.27)440.96 (0.65–1.40)
7824880.65 (0.48–0.87)3030.77 (0.65–0.93)
>7110231.13 (0.68–1.90)430.78 (0.53–1.14)
Ptrend0.0060.02
Single agent nonaspirin NSAID, doses/wk
None1,6541741.005711.00
<78120.27 (0.07–1.13)250.95 (0.59–1.54)
712470.42 (0.19–0.94)380.83 (0.56–1.22)
>721570.21 (0.09–0.46)670.72 (0.52–0.98)
Ptrend<0.00010.18
Any combination of NSAID, doses/wk
Never1,6541741.005711.00
<73871.25 (0.52–3.04)140.79 (0.41–1.51)
78550.32 (0.12–0.83)390.95 (0.63–1.45)
>718180.23 (0.11–0.50)520.51 (0.36–0.72)
Ptrend0.00030.002
  • aAdjusted for age, gender, race, family history, education level, BMI, energy intake, smoking status, alcohol use, physical activity, use of hormone replacement therapy, indication for colonoscopy, study site, and year of study enrollment.