Table 5.

Association between aspirin and NSAID use and adenomatous and hyperplastic polyp risk stratified by polyp location, the TCPS

Adenomatous polyp
ProximalDistalRectal
ExposuresControlnORa(95% CI)nORa(95% CI)nORa(95% CI)
NSAID use
Never1,6542681.002531.00591.00
Baby aspirin only7011390.90 (0.71–1.15)1000.72 (0.55–0.94)330.99 (0.62–1.57)
Regular aspirin only352660.79 (0.58–1.08)510.61 (0.43–0.87)170.92 (0.51–1.67)
Nonaspirin NSAIDs only343600.90 (0.65–1.24)380.57 (0.39–0.84)100.73 (0.36–1.50)
Any combination of NSAIDs304530.69 (0.49–0.98)330.46 (0.30–0.69)131.00 (0.52–1.91)
Hyperplastic polyps
ProximalDistalRectal
ControlnORa(95% CI)nORa(95% CI)nORa(95% CI)
NSAID use
Never1,654361.00821.00861.00
Baby aspirin only701160.81 (0.43–1.51)410.93 (0.61–1.42)220.56 (0.34–0.93)
Regular aspirin only35250.52 (0.98–1.07)291.13 (0.70–1.83)190.84 (0.49–1.45)
Nonaspirin NSAIDs only34370.77 (0.33–1.79)241.01 (0.61–1.65)130.58 (0.31–1.09)
Any combination of NSAIDs30460.73 (0.29–1.84)120.54 (0.28–1.04)190.91 (0.52–1.58)
  • aAdjusted for age, gender, race, family history, education level, BMI, energy intake, smoking status, alcohol use, physical activity, use of hormone replacement therapy, indication for colonoscopy, study site, and year of study enrollment.