Table 4.

Median (range) estrone sulfate, estradiol, and breast percent density at baseline, and changes in breast density, estradiol, and estrone sulfate, expressed as a percentage of baseline values, by CYP19 genotype

Baseline value—median (range)% change from baseline at 12 mo
AAACCCAAACCCP
n = 4n = 17n = 33n = 4n = 17n = 33
Estradiol (pmol/L)23.5 (6.9 to 35.0)19.0 (7.2 to 53.0)24.0 (7.3 to 112.0)−84 (−95 to −48)−85 (−89 to −80)−88 (−91 to −84)0.54
Estrone sulfate (pmol/L)867 (358 to 968)531 (115 to 3,086)679 (214 to 3,500)−95 (−98 to −86)−92 (−95 to −86)−94 (−95 to −92)0.40
Breast density (%)17.9 (5.5 to 66.2)10.7 (0.1 to 58.6)14.5 (0.7 to 46.1)−58 (−97 to 483)−19 (−47 to 25)−7 (−23 to 12)0.10

NOTE: Values in the right side of table represent percent changes [mean (95% CI)] from baseline (negative values indicate decreases from baseline). P values are based on ANOVA comparing genotypes where log-transformed values were analyzed to adhere to the normality assumption.