Table 2.

Changes in breast density, estradiol, and estrone sulfate, expressed as a percent change from baseline values

Baseline—median (range)6 mo—median (range)% change at 6 mo, mean (95% CI)P12 mo—median (range)% change at 12 mo, mean (95% CI)P
Estradiol (pmol/L)21 (6.9 to 112)3 (3 to 9.1)−84 (−89 to −82)<0.0013 (3 to 6.7)−87 (−89 to −84)<0.001
Estrone sulfate (pmol/L)647 (115 to 3,500)60 (8.4–248)−92 (−93 to −90)<0.00155 (6.4 to 595)−93 (−94 to −91)<0.001
Breast density (%)13.4 (0.1 to 66.2)13.0 (1.0, 68.7)2 (−18 to 26)0.8710.3 (0.3 to 55.7)−16 (−30 to 2)0.08

NOTE: P values for paired t tests, using log-transformed values to adhere to the normality assumption.