Table 4.

Changes in expression of individual genes, month 6 minus baseline values

Differences within the soy groupDifferences within the control groupP for between-group differences
Gene nameMean fold change ± SDAdjusted PMean fold change ± SDAdjusted PRaw PAdjusted P
Genistein molecular targets
BAX-Hs00180269_m11.15 ± 0.560.1230.98 ± 0.620.8740.1780.654
BCL2-Hs99999018_m11.34 ± 0.580.0171.24 ± 0.820.1090.4990.705
BCL3-Hs00180403_m11.21 ±0.790.1231.11 ± 0.990.5120.5850.705
BIRC5-Hs00153353_m11.79 ± 2.80.1091.91 ± 3.620.150.8870.887
CCND1-Hs00765553_m13.27 ± 8.650.1232.21 ± 3.850.1010.4550.705
CDKN1A-Hs00355782_m11.58 ± 1.40.0351.24 ± 1.280.270.2260.654
CDKN2A-Hs99999189_m11.43 ± 0.90.0251.26 ± 0.820.1010.3490.654
DDIT3-Hs01090850_m11.37 ± 0.920.0351.17 ± 1.110.3530.3420.654
FAS-Hs00163653_m11.32 ± 0.840.0521.01 ± 0.620.9540.0500.447
GREB1-Hs00536409_m14.39 ± 11.30.1062.98 ± 6.740.1090.4690.705
NFKB1-Hs00765730_m11.14 ± 0.430.0891.05 ± 0.480.5490.3150.654
PARP1-Hs00911369_g11.42 ± 0.790.0221.22 ± 1.020.1890.3020.654
PTGS2-Hs00153133_m11.24 ± 0.80.1091.29 ± 1.220.1590.7910.844
TP53-Hs01034253_m11.29 ± 0.710.0351.21 ± 0.730.1090.5950.705
Estrogen-responsive genes
ESR1-Hs00174860_m12.96 ± 4.330.0271.46 ± 1.820.150.0340.447
ESR2-Hs00230957_m12.49 ± 5.250.1091.59 ± 2.510.1660.2980.654
FOXA1-Hs00270129_m12.9 ± 4.640.0351.47 ± 1.760.1230.0560.447
IGF-I-Hs01547657_m12.83 ± 6.740.1221.88 ± 2.230.0460.3690.654
IGFBP5-Hs01052296_m13.2 ± 9.490.1631.63 ± 1.940.10.2820.654
MYB-Hs00920568_m12.44 ± 3.150.0271.3 ± 1.210.1520.0250.447
PGR-Hs01556702_m13.91 ± 7.580.04612.61 ± 68.360.3030.3880.654
SCUBE2-Hs00221277_m14.03 ± 7.160.0352.51 ± 6.10.150.2780.654
TFF1-Hs00907239_m114.31 ± 42.90.10127.87 ± 139.50.250.5260.705
Breast epithelial atypia–associated genes
PRLR-Hs00168739_m12.38 ± 4.010.0821.6 ± 1.890.1010.2440.654
AR-Hs00171172_m13.06 ± 4.560.0271.76 ± 3.310.1710.1220.654
FGFR3-Hs00997397_m118.3 ± 52.50.0896.33 ± 15.850.0890.1460.654
NDRG2-Hs00212263_m11.53 ± 1.80.1091.33 ± 1.610.2160.5790.705
WNT5B-Hs00364142_m11.92 ± 1.920.0252.35 ± 4.540.1090.5550.705
Housekeeping genes
GAPDH-Hs00266705_g11.01 ± 0.160.6971.02 ± 0.160.3540.680.751
HPRT1-Hs01003267_m11.01 ± 0.150.6011 ± 0.150.9540.6530.746