Table 4.

Exercise intervention effects on CRP levels before and after adjustment for body composition changes

Before adjustmentAfter adjustment
Treatment effect ratio of exercise/control (95% CI)aHypothesized mediatorTreatment effect ratio of exercise/control (95% CI)aPmediatorb
0.87 (0.79–0.96)Change in weight0.95 (0.84–1.07)<0.001
Change in percent body fat0.97 (0.86–1.10)<0.001
Change in total body fat0.96 (0.85–1.09)<0.001
Change in intraabdominal fat area0.97 (0.86–1.10)<0.001

NOTE: Top 1% of CRP measures were excluded from analyses.

  • aThe TER was calculated from a general linear model estimating a parameter with antilogarithm corresponding to the ratio of adjusted geometric means for the exercise intervention group over the control group; this ratio was assumed to be common at 6 months and 12 months postrandomization. A ratio less than 1.00 indicates lower CRP levels in exercisers relative to controls at 6 and 12 months; a ratio more than 1.00 indicates a higher CRP levels in exercisers; and a ratio equal to 1.00 indicates no difference between exercisers and controls. The model after adjustment has one more covariate compared with the model before adjustment: change in hypothesized mediator at 6 and 12 months.

  • bP value for the association between mediator and outcome after adjustment for intervention assignment.