Table 2.

Plasma genistein and endocrine parameters in treatment and placebo groups

Soy group (n = 49)Placebo group (n = 49)Between-group
ParameterNEntrySix moEntrySix moDifferenceP
Plasma genistein in units (median and interquartile range), ng/mL
 All patients970 (0–0)174 (113–377)0 (0–0)0 (0–0)174 (113–377)<0.0001
 Postmenopausal440 (0–0)143 (19–383)0 (0–0)0 (0–0)143 (19–383)<0.0001
 Premenopausal530 (0–0)205 (124–374)0 (0–0)0 (0–0)205 (124–374)<0.0001
Median plasma estradiol (median and interquartile range), pg/mL
 All patients9726.12 (12.73–54.59)26.01 (15.68–59.16)17.01 (10.18–38.52)21.74 (13.46–55.89)4.12 (−6.52 to 17.91)0.77
 Postmenopausal4411.54 (6.61–16.62)16.46 (12.70–20.59)10.31 (9.33–16.62)14.04 (12.00–19.20)2.90 (−1.54 to 9.01)0.36
 Premenopausal5345.29 (28.71–72.35)47.82 (26.63–72.93)36.32 (20.38–70.43)51.94 (43.38–72.92)8.94–19.86 to 33.42)0.57
Median SHBG (median and interquartile range), nmol/L
 All patients9761.25 (45.52–104.35)71.30 (47.22–97.34)85.84 (55.26–118.71)78.47 (55.84–111.85)−5.34 (−18.82 to 15.11)0.43
 Postmenopausal4478.01 (54.98–100.97)72.94 (56.59–119.38)103.37 (58.27–122.09)86.05 (57.19–121.63)−4.98 (−17.82 to 15.28)0.57
 Premenopausal5355.13 (39.56–105.54)63.21 (42.85–91.02)77.28 (51.79–118.71)74.65 (53.68–111.85)−5.34 (−21.44 to 9.45)0.56
Median ratio of estradiol to SHBG (median and interquartile range)
 All patients970.32 (0.18–0.83)0.37 (0.20–0.87)0.24 (0.12–0.51)0.40 (0.12–0.80)0.08 (−0.05 to 0.26)0.48
 Postmenopausal440.16 (0.10–0.21)0.20 (0.13–0.34)0.14 (0.08–0.19)0.18 (0.09–0.36)0.03 (−0.02 to 0.11)0.72
 Premenopausal530.73 (0.37–1.31)0.67 (0.37–1.15)0.46 (0.30–0.77)0.80 (0.50–1.10)0.15 (−0.23 to 0.58)0.28
Median FSH (median and interquartile range), mIU/mL
 All patients9710.90 (5.53–69.76)17.43 (5.17–84.79)34.78 (4.24–72.62)49.67 (5.80–77.77)2.75 (−4.15 to 11.66)0.45
 Postmenopausal4471.72 (48.73–90.67)85.63 (76.52–93.54)70.85 (50.23–96.13)77.40 (65.82–95.68)6.75 (−4.09 to 26.87)0.72
 Premenopausal535.73 (2.46–8.30)6.01 (0.01–9.64)4.24 (1.50–12.92)5.80 (0.01–20.97)0.00 (−4.15 to 5.87)0.80