Entity | State variable | Initial/default value | Units |
---|---|---|---|

Global | • Motility mutation | 0.01 | SD |

• Neoplastic mutation | 0.01 | Rate per cell division | |

• Rate of renewal | 0.1 | Resource per time step | |

• Diffusion rate | 0.001 | Proportion of resource per time step | |

• Death threshold | 1 | Resource level in a patch | |

• Reproduction threshold | 50 | Energy in a cell | |

⇒ Number cells | 2,601 | Count | |

⇒ Number normal | 2,601 | Count | |

⇒ Number neoplastic | 0 | Count | |

Microenvironments | • Location | (−25 − 25, −25 −25) | Coordinates |

• Resource | Random from uniform distribution 0–50 | Resource | |

Cells | • Metabolic rate | 0.5, 1, 1.5, 2, 2.5, 3 | Energy per time step |

• Energy | 5 | Energy in a cell | |

⇒ Motility rate | 0.001 | Probability | |

• Heading | Random from uniform distribution 0–359 | Degrees | |

• Location | One cell was placed in the middle of each patch | Continuous coordinates |

NOTE: Bold indicates the independent variable, and arrows indicate dependent variables.