Table 3.

Intervention induced changes in systemic biomarkers

Polyphenon EPlacebo
n = 24n = 22P
PSA
 Baseline, ng/mL5.63 ± 4.18a7.14 ± 6.700.43b
 Absolute change, ng/mL−0.66 ± 2.56−0.08 ± 1.280.26b
N (%) showing a decrease in PSA14 (58.3)8 (36.4)0.15c
8-OHdG/dG ratio (×105)n = 20n = 17
 Baseline8.89 ± 5.256.75 ± 2.750.16b
 Absolute change−0.79 ± 6.751.81 ± 8.370.17b
N (%) showing a decrease in 8-OHdG13 (65.0)6 (35.3)0.10c
IGF-1n = 24n = 22
 Baseline, ng/mL109.27 ± 41.63107.46 ± 36.090.96b
 Absolute change, ng/mL−6.89 ± 20.97−1.20 ± 21.820.53b
N (%) showing a decrease in IGF-113 (54.2)8 (36.4)0.25c
IGFBP-3n = 24n = 22
 Baseline, ng/mL1,958.77 ± 572.302,118.99 ± 417.850.31b
 Absolute change, ng/mL20.38 ± 289.3−74.76 ± 238.110.24b
N (%) showing an increase in IGFBP-313 (54.2)8 (36.4)0.25c
IGF-1/IGFBP-3n = 24n = 22
 Baseline0.059 ± 0.0220.052 ± 0.0180.27b
 Absolute change−0.003 ± 0.0110.002 ± 0.0130.16b
N (%) showing a decrease in IGF ratio15 (62.5)10 (45.5)0.37c
  • aMean ± SD.

  • bDerived from a Wilcoxon rank-sum test.

  • cDerived from a Fisher exact test.