Table 2.

Significant results in SNP analysis adjusting for clinical variables

Most significant results in 3 genetic models
Whole case–control data setCOPD patients without lung cancer and healthy control data setCOPD patients with lung cancer and healthy control data set
PathwayGeners IDOR (99% CI)P*OR (99% CI)P*OR (99% CI)P*Minimum P*
GSHABCC1rs169677551.51 (1.08–2.10)1.60 × 10−31.50 (0.95–2.38)2.36 × 10−21.45 (1.00–2.10)1.01 × 10−21.60 × 10−3
GSHABCC4rs73242831.90 (1.07–3.37)3.93 × 10−32.40 (1.17–4.91)1.60 × 10−31.58 (0.83–3.04)6.88 × 10−21.60 × 10−3
GSHGCLCrs125245502.42 (1.11–5.28)3.54 × 10−32.60 (0.92–7.34)1.79 × 10−22.11 (0.91–4.90)2.28 × 10−23.54 × 10−3
GSHGCLCrs21003750.75 (0.58–0.97)3.66 × 10−30.33 (0.10–1.04)1.25 × 10−20.78 (0.58–1.03)2.29 × 10−23.66 × 10−3
GSHABCC3rs80754060.70 (0.50–0.97)4.88 × 10−30.65 (0.41–1.02)1.45 × 10−20.70 (0.48–1.01)1.17 × 10−24.88 × 10−3
GSHABCC4rs17297861.61 (1.01–2.56)8.91 × 10−31.43 (1.03–2.00)5.67 × 10−31.59 (0.94–2.70)2.29 × 10−25.67 × 10−3
GSHGCLCrs5429140.78 (0.62–0.99)6.26 × 10−30.80 (0.58–1.11)7.70 × 10−20.78 (0.60–1.02)1.68 × 10−26.26 × 10−3
GSHGCLCrs47120351.37 (1.01–1.86)7.01 × 10−31.38 (0.86–2.21)8.41 × 10−21.36 (0.97–1.90)1.76 × 10−27.01 × 10−3
GSHGSTP1rs11382720.64 (0.41–1.00)9.80 × 10−30.76 (0.42–1.36)2.20 × 10−10.60 (0.36–0.99)8.19 × 10−38.19 × 10−3
GSHABCC2rs7176201.28 (0.96–1.72)2.77 × 10−21.87 (0.57–6.12)1.74 × 10−11.39 (1.01–1.94)8.80 × 10−38.80 × 10−3
GSHGSSrs60886590.29 (0.09–0.99)9.22 × 10−30.39 (0.07–2.06)1.47 × 10−10.23 (0.05–1.01)1.06 × 10−29.22 × 10−3
GSHABCC2rs27561090.79 (0.62–1.00)9.34 × 10−30.69 (0.43–1.11)4.35 × 10−20.80 (0.61–104)2.55 × 10−29.34 × 10−3
GSHABCC1rs2151000.65 (0.38–1.12)3.99 × 10−20.65 (0.30–1.41)1.52 × 10−10.76 (0.58–1.00)9.69 × 10−39.69 × 10−3
DNAMSH3rs125135494.04 (0.72–22.80)3.75 × 10−28.68 (1.36–55.26)2.63 × 10−31.35 (0.89–2.05)6.64 × 10−22.63 × 10−3
DNAXPArs18009750.85 (0.62–1.18)2.05 × 10−10.60 (0.38–0.94)3.33 × 10−30.99 (0.69–1.42)9.26 × 10−13.33 × 10−3
DNAPARPrs118429151.26 (0.93–1.69)4.79 × 10−21.53 (1.02–2.28)6.43 × 10−31.14 (0.77–1.68)3.81 × 10−16.43 × 10−3
DNAERCC2rs39168741.31 (1.01–1.70)7.40 × 10−31.56 (1.00–2.46)1.08 × 10−21.28 (0.96–1.71)2.63 × 10−27.40 × 10−3
DNAMSH3rs330130.72 (0.52–1.00)1.01 × 10−20.80 (0.51–1.26)2.11 × 10−10.69 (0.48–0.99)8.42 × 10−38.42 × 10−3
DNAMSH3rs125221322.17 (0.58–8.09)1.31 × 10−14.49 (1.03–19.52)8.54 × 10−31.22 (0.83-1.82)1.86 × 10−18.54 × 10−3
DNAMSH3rs28972982.28 (0.62–8.32)1.03 × 10−14.48 (1.03–19.47)8.58 × 10−31.21 (0.81–1.79)2.17 × 10−18.58 × 10−3
InflammationPTGS2rs6894702.26 (0.96–5.36)1.47 × 10−23.02 (1.05–8.71)7.03 × 10−31.96 (0.72–5.32)8.41 × 10−27.03 × 10−3
  • *Bold P-values mean below significant value of 0.01.