Significant results adjusting for clinical variables in gene-based analysis*
| Minimum P value in 3 genetic models | ||||||
|---|---|---|---|---|---|---|
| Pathway | Gene | Number of SNPs tested | Whole case–control data set | COPD patients without lung cancer and healthy control data set | COPD patients with lung cancer and healthy control data set | Minimum P Value |
| GSH | GCLC | 13 | 4.04 × 10−7 | 1.81 × 10−4 | 7.16 × 10−4 | 4.04 × 10−7 |
| GSH | GSS | 7 | 3.61 × 10−2 | 1.14 × 10−4 | 1.75 × 10−2 | 1.14 × 10−4 |
| GSH | GSTO2 | 6 | 3.30 × 10−3 | 5.05 × 10−1 | 1.06 × 10−3 | 1.06 × 10−3 |
| DNA | ERCC1 | 5 | 5.26 × 10−1 | 8.11 × 10−3 | 8.28 × 10−1 | 8.11 × 10−3 |
| DNA | RRM1 | 6 | 9.66 × 10−3 | 2.09 × 10−2 | 8.71 × 10−2 | 9.66 × 10−3 |
*Bold P-values mean below significant value of 0.01.