Table 3.

Significant results adjusting for clinical variables in gene-based analysis*

Minimum P value in 3 genetic models
PathwayGeneNumber of SNPs testedWhole case–control data setCOPD patients without lung cancer and healthy control data setCOPD patients with lung cancer and healthy control data setMinimum P Value
GSHGCLC134.04 × 10−71.81 × 10−47.16 × 10−44.04 × 10−7
GSHGSS73.61 × 10−21.14 × 10−41.75 × 10−21.14 × 10−4
GSHGSTO263.30 × 10−35.05 × 10−11.06 × 10−31.06 × 10−3
DNAERCC155.26 × 10−18.11 × 10−38.28 × 10−18.11 × 10−3
DNARRM169.66 × 10−32.09 × 10−28.71 × 10−29.66 × 10−3
  • *Bold P-values mean below significant value of 0.01.