Table 4.

Cumulative risk prediction model for COPD based on multiple independent high-risk htSNP combination

Number of risk allelesNumber of COPD casesNumber of healthy controlsORS × 10ZP
Whole case–control data set (12 risk htSNPs included)
 First level (0, 9)992191.00 (reference)
 Second level (10, 12)2804241.620.172.913.60 × 10−3
 Third level (13, 24)2412502.730.185.612.07 × 10−8
 Per-allele risk (trend test)1.210.036.711.95 × 10−11
COPD patients without lung cancer and healthy control data set (8 risk htSNPs included)
 First level (0, 2)302471.00 (reference)
 Second level (3, 5)1084961.670.242.192.83 × 10−2
 Third level (6, 16)501503.080.284.084.60 × 10−5
 Per-allele risk (trend test)1.250.054.761.94 × 10−6
COPD patients with lung cancer and healthy control data set (4 risk htSNPs included)
 First level (0, 4)1243241.00 (reference)
 Second level (5, 6)2645091.890.154.192.81 × 10−5
 Third level (7, 8)44602.320.273.101.94 × 10−3
 Per-allele risk (trend test)1.300.064.449.16 × 10−6