Cumulative risk prediction model for COPD based on multiple independent high-risk htSNP combination
| Number of risk alleles | Number of COPD cases | Number of healthy controls | OR | S × 10 | Z | P |
|---|---|---|---|---|---|---|
| Whole case–control data set (12 risk htSNPs included) | ||||||
| First level (0, 9) | 99 | 219 | 1.00 (reference) | |||
| Second level (10, 12) | 280 | 424 | 1.62 | 0.17 | 2.91 | 3.60 × 10−3 |
| Third level (13, 24) | 241 | 250 | 2.73 | 0.18 | 5.61 | 2.07 × 10−8 |
| Per-allele risk (trend test) | 1.21 | 0.03 | 6.71 | 1.95 × 10−11 | ||
| COPD patients without lung cancer and healthy control data set (8 risk htSNPs included) | ||||||
| First level (0, 2) | 30 | 247 | 1.00 (reference) | |||
| Second level (3, 5) | 108 | 496 | 1.67 | 0.24 | 2.19 | 2.83 × 10−2 |
| Third level (6, 16) | 50 | 150 | 3.08 | 0.28 | 4.08 | 4.60 × 10−5 |
| Per-allele risk (trend test) | 1.25 | 0.05 | 4.76 | 1.94 × 10−6 | ||
| COPD patients with lung cancer and healthy control data set (4 risk htSNPs included) | ||||||
| First level (0, 4) | 124 | 324 | 1.00 (reference) | |||
| Second level (5, 6) | 264 | 509 | 1.89 | 0.15 | 4.19 | 2.81 × 10−5 |
| Third level (7, 8) | 44 | 60 | 2.32 | 0.27 | 3.10 | 1.94 × 10−3 |
| Per-allele risk (trend test) | 1.30 | 0.06 | 4.44 | 9.16 × 10−6 | ||