Table 2.

Preoperative characteristics in relation to adherence for the 417 patients with ER-positive tumors who had received or had been advised to take endocrine treatment

Total number of patients, 1-y follow-up (%), N = 417Adherent, 1-y follow-up (%), N = 381Nonadherent, 1-y follow-up (%), N = 36RR (95% CI)PTotal number of patients, 2-y follow-up (%), N = 339Adherent, 2-y follow-up (%), N = 306Nonadherent, 2-y follow-up (%), N = 33RR (95% CI)P
Age, y
 <60201 (48.2)183 (91.0)18 (9.0)1.07 (0.58–2.01)0.82167 (49.3)149 (89.2)18 (10.8)1.24 (0.64–2.37)0.52
 ≥60216 (51.8)198 (91.7)18 (8.3)1172 (50.7)157 (91.3)15 (8.7)1
 Missing000000
BMI, kg/m2
 <25215 (52.1)188 (87.4)27 (12.6)2.77 (1.33–5.73)0.004183 (54.5)160 (87.4)23 (12.6)1.92 (0.94–3.91)0.064
 ≥25198 (47.9)189 (95.5)9 (4.5)1153 (45.5)143 (93.5)10 (6.5)1
 Missing440330
WHR
 ≤0.85235 (56.6)213 (90.6)22 (9.4)1.20 (0.63–2.29)0.57201 (59.3)180 (89.6)21 (10.4)1.18 (0.60–2.33)0.62
 >0.85180 (43.4)166 (92.2)14 (7.8)1136 (40.4)124 (91.2)12 (8.8)1
 Missing220220
Alcohol use
 Never40 (9.6)36 (90.0)4 (10.0)35 (10.4)29 (82.9)6 (17.1)
 Not more than once a mo102 (24.5)89 (97.3)13 (12.7)1.73 (0.93–3.22)0.08385 (25.1)76 (89.4)9 (10.6)1.51 (0.79–2.89)0.21
 2–3 times/mo162 (38.9)151 (93.2)11 (6.8)124 (36.7)113 (91.1)11 (8.9)
 2–3 times/wk91 (21.9)85 (93.4)6 (6.6)174 (21.9)68 (91.9)6 (8.1)1
 4 or more times/wk21 (5.0)19 (90.5)2 (9.5)20 (5.9)19 (95.0)1 (5.0)
 Missing110110
Smoker
 Yes80 (19.2)65 (81.2)15 (18.8)3.01 (1.62–5.57)0.000365 (19.2)52 (80.0)13 (20.0)2.74 (1.44–5.22)0.002
 No337 (80.8)316 (94.8)21 (6.2)1274 (19.2)254 (92.7)20 (7.3)1
 Missing000000
Natural remedy use
 Yes98 (23.6)88 (89.8)10 (10.2)1.25 (0.62–2.50)0.5381 (24.0)73 (90.1)8 (9.9)1.02 (0.48–2.16)0.97
 No318 (76.4)292 (91.8)26 (8.2)1257 (76.0)232 (90.3)25 (9.7)1
 Missing110110
Antidepressant use
 Yes44 (10.6)40 (90.9)4 (9.1)1.06 (0.39–2.86)0.9133 (9.7)30 (90.9)3 (9.1)0.93 (0.11–2.87)0.90
 No373 (89.4)341 (91.4)32 (8.6)1306 (90.3)276 (90.2)30 (9.8)1
 Missing000000
Psychiatric medication use (sedatives, sleeping pills, antidepressants)
 Yes83 (20.0)74 (89.2)9 (10.8)1.34 (0.66–2.74)0.4264 (18.9)55 (85.9)9 (14.1)1.61 (0.79–3.30)0.19
 No334 (80.0)307 (91.9)27 (8.1)1275 (81.1)251 (91.3)24 (8.7)1
 Missing000000
Number of medications last
 <2221 (53.0)202 (91.4)19 (8.6)1181 (53.4)162 (89.5)19 (10.5)1
 ≥2196 (47.0)179 (91.3)17 (8.7)1.01 (0.54–1.89)0.98158 (46.6)144 (91.1)14 (8.9)0.84 (0.12–1.63)0.61
 Missing000000
Family history of breast cancer (first- or second-degree relatives)
 Yes147 (36.8)135 (91.8)12 (8.2)1111 (34.2)100 (90.1)11 (9.9)1
 No253 (63.3)229 (90.5)24 (9.5)1.16 (0.60–2.25)0.66214 (65.8)192 (89.7)22 (10.3)1.04 (0.52–2.06)0.92
 Missing1717014140
Ever HRT use
 Yes199 (47.8)180 (90.5)19 (9.5)1.22 (0.65–2.28)0.53163 (48.1)146 (89.6)17 (10.4)1.14 (0.60–2.18)0.69
 No217 (52.2)200 (92.2)17 (7.8)1175 (51.8)159 (90.9)16 (9.1)1
 Missing110110