Table 2.

Univariate and multivariate analyses of predictors of HCC occurrence in the whole population (N = 291).

Univariate analysisMultivariate analysis
VariablesHR (95% CI)PHR (95% CI)P
Age1.03 (1.01–1.05)0.00491.06 (1.04–1.09)<0.0001
BMI1.1 (1.05–1.16)0.00021.09 (1.04–1.15)0.0008
Male sex1.54 (0.92–2.6)0.102.8 (1.53–5.12)0.0008
Mixed etiology0.81 (0.47–1.41)0.46
Diabetes1.42 (0.84–2.4)0.19
AFP1 (1–1)0.84
Prothrombin activity0.99 (0.98–1.01)0.30
Albumin0.96 (0.91–1.01)0.09
Bilirubin1.01 (0.99–1.03)0.49
Platelet count0.99 (0.98–0.99)<0.00010.98 (0.98–0.99)<0.0001
ALT0.97 (0.88–1.07)0.51
AST0.88 (0.7–1.1)0.27
Alkaline phosphatase0.96 (0.59–1.57)0.88
Child–Pugh class B0.19 (0.01–3.08)0.24
GGT0.98 (0.91–1.06)0.65
Propranolol treatment0.44 (0.18–1.11)0.080.25 (0.09–0.65)0.0044

NOTE: Mixed etiology for past or ongoing daily alcohol intake >30 g/d AST, ALT, GGT.

Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, γ-glutamyltransferase.