Table 1.

Summary of the results obtained for the different immunosuppressants

CyclosporineTacrolimusAzathioprineMycophenolate mofetilRapamycin
Human skin modelEpidermal regeneration
Proliferation
Apoptosis after UV
Mouse modelProliferation
Number of mut-p53 cell clusters
P53 mutational frequency in nontumor epidermis
Yield of small tumors (>1 mm)
Yield of large tumors (>4 mm)

NOTE: —, no effect; ↓, inhibitory effect; ↑, stimulatory effect.