Table 1

Histology of the tongues and esophagi in 4NQO-treated mice.

GenotypeNumber of miceDysplasiaSquamous cell carcinomaP value
A. Histology of the tongues in short-term experiment with 4NQO
Wild-type217 (33%)1 (5%)
Keap1-KD203 (15%)2 (10%)0.48
Nrf2-KO2113 (62%)5 (24%)0.0013
B. Histology of the esophagi in short-term experiment with 4NQO
Wild-type2118 (86%)1 (5%)
Keap1-KD206 (30%)0 (0%)<0.001
Nrf2-KO213 (14%)18 (86%)<0.001
C. Histology of the tongues in long-term experiment with 4NQO
Wild-type229 (41%)12 (55%)
Keap1-KD189 (50%)1 (6%)<0.001
D. Histology of the esophagi in long-term experiment with 4NQO
Wild-type228 (36%)14 (64%)
Keap1-KD188 (44%)0 (0%)<0.001

NOTE: P value evaluated in comparison with WT mice.