Table 1.

Quantitative metabolic profile of prostatic tumor tissues of 2 study groupsa

Metabolite1H-NMRSUntreated [μmol/g]2% IP6 [μmol/g]
1.Aromatic acidsHydrophilic12.12 ± 2.3714.94 ± 1.88
2.AdenosinesHydrophilic3.39 ± 0.894.05 ± 0.2
3.NucleotidesHydrophilic1.18 ± 0.771.11 ± 0.07
4.MyoinositolHydrophilic1.17 ± 0.744.48 ± 0.65P = 0.02
5.Polyols + sugarsHydrophilic15.71 ± 4.953.07 ± 14.64P = 0.03
6.TaurineHydrophilic11.90 ± 3.1713.15 ± 0.28
7.PC+GPCHydrophilic2.65 ± 0.477.82 ± 0.44P<0.001
8.Total cholineHydrophilic0.09 ± 0.030.06 ± 0.03
9.Total creatineHydrophilic3.50 ± 0.476.27 ± 1.8
10.GSHHydrophilic0.53 ± 0.170.58 ± 0.05
11.CitrateHydrophilic0.43 ± 0.230.32 ± 0.01
12.MethionineHydrophilic1.86 ± 0.733.53 ± 0.61P<0.001
13.Total glutathioneHydrophilic0.88 ± 0.212.91 ± 0.60P = 0.01
14.GlutamineHydrophilic0.60 ± 0.090.99 ± 0.14P = 0.01
15.SuccinateHydrophilic0.83 ± 0.222.07 ± 0.39P = 0.01
16.GlutamateHydrophilic3.34 ± 0.562.58 ± 0.32P = 0.04
17.Ketone bodiesHydrophilic1.01 ± 0.180.58 ± 0.28P = 0.02
18.Total CH2-, CH3Hydrophilic7.71 ± 1.629.11 ± 0.42
19.AcetateHydrophilic0.02 ± 0.021.91 ± 0.36P = 0.01
20.Lysine + ArginineHydrophilic2.26 ± 0.312.10 ± 0.17
21.AlanineHydrophilic3.19 ± 0.221.60 ± 0.27P < 0.001
22.LactateHydrophilic9.86 ± 0.877.84 ± 1.09
23.HydroxybutyrateHydrophilic0.51 ± 0.171.32 ± 0.34
24.Essential amino acidsHydrophilic4.59 ± 0.724.82 ± 0.04
25.MUFALipids5.44 ± 3.5636.84 ± 18.77P = 0.04
26.TAGLipids6.07 ± 0.318.55 ± 5.61P = 0.03
27.Glycerol-P lipidsLipids14.57 ± 1.6914.04 ± 0.31
28.PtdChoLipids8.07 ± 1.555.67 ± 0.34P = 0.04
29.PtdInsLipids2.32 ± 1.00.94 ± 0.28P = 0.04
30.Total cholines (lipids)Lipids7.74 ± 1.34.68 ± 0.44P = 0.04
31.PtdEthLipids1.95 ± 0.221.17 ± 0.63
32.PUFALipids27.32 ± 2.9327.97 ± 7.45
33.Fatty acidsLipids34.73 ± 7.77108.03 ± 34.58P = 0.02
34.(CH2)n lipidsLipids323.06 ± 65.82777.87 ± 210.28P = 0.02
35.Total lipidsLipids67.30 ± 14.3897.88 ± 19.64P = 0.05
36.CholesterolLipids5.82 ± 0.453.56 ± 0.35P = 0.02
37.[PUFA/MUFA]Lipids6.20 ± 2.830.88 ± 0.35P = 0.03

NOTE: (i) Positive control (untreated) TRAMP mice and (ii) IP6-treated TRAMP mice (2% w/v IP6 in regular drinking water given for 24 weeks).

Abbreviations: Cho, choline; GPC, glycerophosphocholine; GSH, reduced glutathione; MUFA, mono-unsaturated fatty acids; PC, phosphocholine; PtdCho, phosphatidylcholine; PtdEth, phosphatidylethanolamine; and PUFA, poly-unsaturated fatty acids.

  • aAll data are given in μmol of metabolite normalized to prostate tissue weight [μmol/g] and presented as mean ±SD (n = 4 for each group).