Table 1.

Serum levels of erlotinib and its major metabolite OSI-420 in female Sprague–Dawley rats

(i) Erlotinib, 6 mg/kg body weight/day
Hours after final gavageErlotinibOSI-420
2708 ± 48a133 ± 17
4427 ± 1988 ± 13
8277 ± 10258 ± 19
2425 ± 918 ± 5
48010 ± 4
(ii) Erlotinib, 42 mg/kg body weight, 1×/week
Hours after final gavageErlotinibOSI-420
21352 ± 96246 ± 21
41060 ± 184226 ± 32
81590 ± 259323 ± 42
24470 ± 121130 ±36
4852 ± 1113 ± 4
(iii) Controls
None detected
  • aValues are ng/mL of serum; mean ± SEM.