Table 2.

Erlotinib noncompartmental pharmacokinetic parameters in female Sprague–Dawley rats and humans (steady state)

SpeciesDose, mg/kgTmax hoursCmax ng/mLAUC0–24 ng h/mLT1/2 hours
Rat62.007084,6804.61
428.001,59028,4008.06
Human150 (mg)2.441,74026,50024.4