Table 1.

MiRNAs and natural products in cancer chemoprevention

Natural productsModelsUpregulationDownregulationRef
Vitamin AHuman leukemia cellsmiR-15a, miR-15b, miR-16-1, let-7a-3, let-7c, let-7d, miR-223, miR-342, miR-107miR-181b(28, 29)
Human leukemia cellsmiR-186, miR-215, miR-223miR-17-5p, miR-25, miR-193, miR-195, let-7a(30)
Human leukemia cellsmiR-146a(31)
Human breast cancer cellsmiR-21(33)
Vitamin B (folate)Human lymphoblast cellsmiR-222(35)
Fisher ratsmiR-122(36)
Vitamin DHuman leukemia cellsmiR-32(37)
Human leukemia cellsmiR-181(38)
Human breast cancer cellsmiR-182(39)
Human prostate cancer cellsmiR-98(40)
Human colon cancer cells and patient samplesmiR-22(44)
Vitamin EMale Fisher 344 ratsmiR-122a, miR-125b(46)
Fatty acidsRat AOM modellet-7d, miR-15b, miR-107, miR-191, miR-324-5p(48)
CurcuminHuman colon cancer cellsmiR-21(50)
Human pancreatic cancer cellsmiR-22miR-199a(51)
ResveratrolHuman acute monocytic leukemia cellsmiR-663miR-155(53)
Human prostate cancer cellsmiR-17-92, miR-106a/b(54)
EllagitanninsHuman hepatocellular carcinoma cellslet-7e, miR-370, miR-373*, miR-526blet-7a, let-7c, and let-7d(57)
Human hepatocellular carcinoma cellslet-7a, miR-29amiR-197, miR-373(58)
GenisteinHuman uveal melanoma cellsmiR-27(60)
human prostate cancer cellsmiR-221, miR-222(61)
CatechinsHuman malignant neuroblastoma cellsmiR-7-1, miR-34a, miR-99amiR-92, miR-93, miR-106b(62, 63)
Human and mouse lung cancer cellsmiR-210(65)
Human prostate cancer cellsmiR-330miR-21(66)
Human hepatocellular carcinoma cellslet-7a, miR-16, miR-221miR-18a, miR-34b, miR-193b, miR-222, miR-342(67)
Indoles (I3C and DIM)Female A/J micemiR-21, miR-31, miR-130a, miR-146b, miR-377miR-1, miR-143(68)
Human pancreatic cancer cellslet-7b, let-7c, let-7d, let-7e, miR-200b, miR-200c(69)
Human breast cancer cell linemiR-21(70)