Table 3.

Raloxifene metabolites in plasma stratified by UGT1A8 genotype

GroupMetaboliteUGT1A8 (*1/*3)aUGT1A8 (*1/*1)+(*1/*2)aUGT1A8 (*2/*2)a
60 mg raloxifeneRaloxifene-6-Gluc/raloxifene13 (1)31 ± 27 (36)43 ± 21 (5)
Raloxifene-4′-Gluc/raloxifene4294 ± 74146 ± 62
Total raloxifine-Gluc/raloxifine55125 ± 96189 ± 77
30 mg raloxifenebRaloxifene-6-Gluc/raloxifene10 ± 14 (2)27 ± 24 (37)
Raloxifene-4′-Gluc/raloxifene18 ± 993 ± 97
Total raloxifene-Gluc/raloxifene27 ± 23120 ± 120
Combined treatment groupsRaloxifene-6-Gluc/raloxifenec11 ± 10 (3)29 ± 26 (73)43 ± 21 (5)
Raloxifene-4′-Gluc/raloxifened26 ± 1593 ± 86146 ± 62
Total raloxifene-Gluc/raloxifenee37 ± 23123 ± 101189 ± 77
  • aValues are ng/mL. Numbers in parenthesis represent the number of subjects analyzed in each group.

  • bThere were no subjects with the UGT1A8 (*2/*2) genotype in this group.

  • cPtrend = 0.020.

  • dPtrend = 0.003.

  • ePtrend = 0.005.