Table 3.

DNA ploidy status of index lesions by clinical diagnosis for patients with transformation after 6 months

DiagnosisNumber diploidNumber tetraploidNumber aneuploidTotala
Leukoplakia including idiopathic/smoker's keratosis116 (45.3)39 (15.2)34 (13.3)189 (73.8)
Lichen planus or lichenoid reaction19 (7.4)4 (1.6)023 (9)
Erythroplakia1 (0.4)001 (0.4)
Oral submucous fibrosis3 (1.2)003 (1.2)
Chronic hyperplastic candidosis12 (4.7)6 (2.3)6 (2.3)24 (9.4)
Actinic keratosis1 (0.4)001 (0.4)
Otherb7 (2.7)2 (0.8)6 (2.3)15 (5.9)
Total159 (62.1)51 (19.9)46 (18)256 (100)a

NOTE: Number of lesions and percentage of total in parentheses.

  • an = (273 patients less 17 with early transformation) = 256 (Table 1).

  • bIncludes chronic nonspecific ulceration, inflammation, papillary hyperplasia, etc. histologically, but considered as possible risk lesions clinically. Proliferative verrucous leukoplakia not separately identified as malignant transformation is a defining clinical characteristic.