Table 4.

Patient-based analysis of positive and negative predictive values of DNA ploidy and dysplasia grading for patients with and without malignant transformation

Excluding malignant transformation within 6 months of index biopsyIncluding malignant transformation within 6 months of index biopsy
PPV%NPV%PPV%NPV%
DNA aneuploidy number of casesn = 256n = 273
DNA aneuploidy15.234
DNA diploid or tetraploid96.694.4
DNA aneuploidy + dysplasia number of casesn = 110n = 119
DNA aneuploidy in cases with any degree of dysplasia27.339
DNA diploid or tetraploid in cases with any degree of dysplasia92.290
Dysplasia number of casesn = 1,379n = 1,401
Severe dysplasia20.798.439.597.5
Moderate dysplasia10.198.918.498.4
Moderate or severe13.398.925.498.4
Mild dysplasia3.999.1698.8
No dysplasia0.8591.51ยท184
DNA ploidy subset number of casesn = 110n = 119
Severe dysplasia in the DNA ploidy subset only23.588.238.184.7
Moderate dysplasia in the DNA ploidy subset only3592.322.290.6
Moderate or severe dysplasia in the DNA ploidy subset only18.992.327.390.6
Mild dysplasia in the DNA ploidy subset only7.781.09.472.7

NOTE: Cases transforming within 6 months of the index biopsy are shown separately. Data for the cases in the DNA ploidy subset are shown for comparison. Predictive values of most significance for clinical management of an initial biopsy are shown in bold. % and number of cases from which the data are derived above.